高血压、冠心病与血尿酸水平关系的临床观察

Clinical investigation of the correlation among hyperuricenlia and hypertension,coronary heart disease

目的:探讨高血压、冠心病与血尿酸水平的关系。方法:测定40例高血压,20例冠心病患者及20例对照组(胆囊炎、胆石症术后)的血尿酸水平并进行对比。结果:高血压、冠心病组血尿酸水平明显高于对照组,尤以高血压组的升高更加明显(P分别<0.01,<0.05).其总胆红素水平也高于对照组(P<0.01,<0.05)。结论:血尿酸水平升高与高血压和冠心病有密切的关系,已成为高血压的独立危险因素。故降压治疗时要注意保护肾脏,应用降血尿酸水平的药物。

Objective: To study the correlation among hyperuricemia and hypertension, coronary heart disease (CHD). Methods: Serurn uric acid was measured respectively and compared in 40 patients with hypertension. 20 patients with CHD and 20 patienls as control subjects, who had been performed cholecystectomy. Results: The level of serum uric acid was significantly higher in patients with hypertension, CHD than those in control subjects, especially in patients with hypertension (P<0. 01, <0. 05 respectivly) ; the level of total bilirubin had the similar result. Conclusion: There was an obvious correlation among hypertension, CHD and hyperuricemia, which was an independent risk factor in hypertension. So drugs being applied should have the function of not only reducing blood pressure but also to protect renal function reducing level of serum uric acid.