卡托普利对急性心肌梗死后室壁瘤形成的影响

Effects of treatment with captopril on ventricular aneurysm formation after acute myocardial infarction

目的:观察口服卡托普利对急性心肌梗死(AMI)后室壁瘤(VA)形成的影响。方法:住院首发AMI患者151例,年龄≥60岁,按是否口服卡托普利随机分为观察组及对照组。于病后4周行心脏二维超声检查.其中7例经左室造影,观察VA形成情况。结果:观察组89例,有VA形成9例,占10％;对照组62例,有VA形成21例,占34％(P<0.05)。心功能(killip)Ⅱ～Ⅲ级者:观察组6.7％(6/89),对照组18％(11/62),(P<0.05)。结论:口服卡托普利能减轻、延缓心室重构程度,减少VA形成,降低病死率。

Objective: To observe the effects of treatment with oral captopril to reduce incidence of VA after AMI. Methods: One hundred and fifty one AMI patients were divided into observe groups (n = 89, treatment with captopril 12.5 mg. three times a day) and control group (n = 62). All patients were measured by two-dimension echo cartography after 2 to 4 weeks (7 cases by left ventriculography). Results: Patients complicated with VA occurred 10% (9/89) in observe group, 34% (21/62) in control group (P<0. 05). Patients with heart function (killip) grade Ⅱ - Ⅲ occurred 6-7% (6/89) in observe group, 18% (11/62) in control group. Conclusion: The results suggest that treatment with captopril seems can improve left ventricular remodeling and reduce the incidence of VA after AMI.