摘要
目的:探讨2型糖尿病血清肿瘤坏死因子与胰岛素抵抗之间的关系。方法:用氧化酶法,放免法和酶联免疫法分别测定正常健康人23例,2型糖尿病28例的空腹血糖、空腹胰岛素(Fins)、血清TNF-α。计算胰岛素敏感指数(ISI)。结果:2型糖尿病TNF-α水平较正常对照组升高(P<0.01),而ISI较正常组降低(P<0.01)。结论:2型糖尿病TNF-α水平增高与胰岛素抵抗有关,可能参与2型糖尿病的发生和发展。
Objective:To explore the relationship between sera TNFalevels and insulin resistance in patients with type 2 diabetes. Methods: 23 healthy persons (control group) ,28 cases of type-2 diabetes mellitus were selected to determine fasting blood glucose, fasting blood-insulin and serum TNF-a by oxidase method, RIA and ELISA. Insulin sensitivity index(ISI) was calculated. Results:TNF-a levels were significantly higher while ISI lower in DM group than those in control group(P<0. 01). Conclusions. In type 2 diabetes mellitus the level of TNF-a increased and it was negatively correlated to ISI, which plays an important role in the development of the disease.
出处
《中国误诊学杂志》
CAS
2003年第10期1469-1470,共2页
Chinese Journal of Misdiagnostics
