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192例IgA肾病小管间质损害的临床与病理研究 被引量:2

Clinical study of tubulointerstitial lesions in 192 patients with IgA nephropathy
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摘要 目的 :探讨肾小管间质损害在IgA肾病的临床重要性。方法 :分析 192例IgA肾病的临床与病理资料。结果 :IgA肾病伴有肾小管间质损害占 85 .4 % ,其中轻度损害占 4 6 .9% ,中度损害占 2 0 .8% ,重度损害占 17.7% ,无损害占 14 .6 %。临床上血压升高、尿蛋白定量增多及肾功能减退是IgA肾病预后不良的临床因素。肾小球各项病理指标 :血管损害、肾小球总体损害、系膜增殖程度及球性硬化的积分随着肾小管间质的损害程度增加 ,二者呈平行关系。结论 :肾小管间质损害在IgA肾病病理改变中广泛存在。随着其损害程度的加重 ,IgA肾病的病情逐渐加重 ,提示肾小管间质损害是决定IgA肾病预后不良的关键因素之一。 Objective:To analyze the importance of tubulointerstitial lesions(TIL) in IgA Nephropathy(IgAN).Methods:The pathologic and clinical materials of 192 IgAN patients were analyzed.Results:The patients of TIL were about 85.4% in IgAN,mild TIL accounted for 46.9%, moderate TIL 20.8%, severe TILwas about 17.7% and these without TIL14.6%. Relationship between TIL and the pathologic findings: with increase of the severity of TIL, the scores of vascular lesion , total glomerular lesion, hypercellularity and glomeruloselerosis increased gradually.Conclusion:With the increase of the severity of TIL. the condition of IgAN patients became worse .TIL may be one of the key factors for the prognosis of IgAN.
出处 《中国中西医结合肾病杂志》 2003年第10期589-591,共3页 Chinese Journal of Integrated Traditional and Western Nephrology
关键词 IGA肾病 肾小管间质损害 预后 原发性肾小球疾病 IgA Nephropathy Tubulointerstitial Interstitial Symtoms and general pathology
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参考文献7

  • 1潘缉圣.IgA肾病[A].王海燕主编.肾脏病学[C].北京:人民卫生出版社,1997.708~719.
  • 2聂莉芳.IgA肾病血尿的中医辨治[J].中国中西医结合肾病杂志,2001,2(11):621-622. 被引量:50
  • 3杨剑辉,张纪芸,王艳侠.IgA肾病肾病综合征的临床和病理研究[J].中国中西医结合肾病杂志,2001,2(11):641-643. 被引量:3
  • 4Churg J, Bemstein J, Glassock RJ. Renal Disease Classification and atlas of glomerular disease, second edition . New York: Ikagu - shoin, 1995.4 - 5.
  • 5Schena FP. IgA Nephropathies. In: Cameron JS. Davison A M. Oxford Textbook of Clincal Nephrology . Vol I , 1st ed , Oxford , Oxford University press, 1992,339 - 369.
  • 6Katafuchi R, Kiyoshi Y, Oh Y,et al.Glomerular score as a pro- gnosticator in IgA nephropathy: its usefulness and limitation. Clin Nephrol, 1998,49,1 - 8.
  • 7Alamartine E, Sabatier JC, Guerin C, et al. Porgnostic factors in mesangial IgA glomerulonephritis:an extensive study with univariate and multivariate analysis. Am J Kidney Dis,1991,18:12 - 19.

二级参考文献6

  • 1杨剑辉,黎磊石,周虹.肉眼血尿型和肾病综合征型IgA肾病的临床与病理对照[J].中华肾脏病杂志,1995,11(3):159-160. 被引量:10
  • 2Ibels LS, Gyory AZ. IgA nephropathy: Analysis of the nature history, important factors in progression of renal disease and review of literature. Medine, 1994,73: 79.
  • 3Bole A Gise HV, Stark JB. The oliteration of postglomerular capillaries and its influence upon the function of both glomeruli and tubuli. Clin Wochenchr, 1983,54: 104.
  • 4Biondo B, Grosso E, Fogato E, et al. Glomerular morphometry of twenty- three biopsied patients with lgA nephropathy. Am J Nephrol, 1995,15: 99.
  • 5Buzzi C,Petrini C, Rizza V, et al. A mordem approach to seletivity of proteinuria and tubulointerstitial damage in nephrotic syndrome. Kidney Int,2000,58(5): 1732.
  • 6Suzuki S, Sato S, Kobayashi H, et al. Comparative study of IgA nephropathy with acute and insidious onset: clinical, laboratory and pathological findings. Am J Nephrol, 1992,12:22.

共引文献54

同被引文献14

  • 1房向东,杨丽萍,黄天伦.24例IgA肾病肾小管间质损害的临床与病理[J].中国现代医学杂志,2007,17(8):999-1001. 被引量:9
  • 2傅鹏,于光,许静,梅小斌,吴灏,袁伟杰.来氟米特联合激素延缓进展型IgA肾病肾功能减退的临床研究[J].临床内科杂志,2006,23(11):731-733. 被引量:23
  • 3陈洪滔,许慧丽,廖莹,栾韶东,万启军,何永成.IgA肾病肾小管间质病变与临床及病理的关系[J].临床内科杂志,2007,24(5):319-321. 被引量:12
  • 4Li LS,Liu ZH.Epidemilogic data of renal disease from a single unit in China:analysis based on 13,519 renal biopsies.Kidney Int,2004,66(3):920-923.
  • 5Daniel L,Saingra Y,Giorgi R,et al.Tubular lesions determine prognosis of IgA nephropathy.Am J Kidney Dis,2000,35(1):13-20.
  • 6Lee SM,Rao VM,Franklin WA,et al.IgA nephropathy:morphologic predictors of progressive renal disease.Hum Pathol,1982,13(4):314-322.
  • 7Katafuchi R,Oh Y,Hori K,et al.An important role of glomerular segmental lesions on progression of IgA nephropathy:a multivariate analysis.Clin Nephrol,1994,41(4):191-198.
  • 8Floege J.The pathogenesis of IgA nephropathy:what is new and how does it change therapeutic approaches? Am J Kidney Dis,2011,58(6):992-1004.
  • 9Lai KN,Tang SC,Leung JC.Recent advances in IgA nephropathy--the glomerulopodocytic-tubular communication.Adv Otorhinolaryngol,2011,72(1):40-44.
  • 10Lai KN.Pathogenesis of IgA nephropathy.Nat Rev Nephrol,2012,8(5):275-283.

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