摘要
目的 :探讨肾小管间质损害在IgA肾病的临床重要性。方法 :分析 192例IgA肾病的临床与病理资料。结果 :IgA肾病伴有肾小管间质损害占 85 .4 % ,其中轻度损害占 4 6 .9% ,中度损害占 2 0 .8% ,重度损害占 17.7% ,无损害占 14 .6 %。临床上血压升高、尿蛋白定量增多及肾功能减退是IgA肾病预后不良的临床因素。肾小球各项病理指标 :血管损害、肾小球总体损害、系膜增殖程度及球性硬化的积分随着肾小管间质的损害程度增加 ,二者呈平行关系。结论 :肾小管间质损害在IgA肾病病理改变中广泛存在。随着其损害程度的加重 ,IgA肾病的病情逐渐加重 ,提示肾小管间质损害是决定IgA肾病预后不良的关键因素之一。
Objective:To analyze the importance of tubulointerstitial lesions(TIL) in IgA Nephropathy(IgAN).Methods:The pathologic and clinical materials of 192 IgAN patients were analyzed.Results:The patients of TIL were about 85.4% in IgAN,mild TIL accounted for 46.9%, moderate TIL 20.8%, severe TILwas about 17.7% and these without TIL14.6%. Relationship between TIL and the pathologic findings: with increase of the severity of TIL, the scores of vascular lesion , total glomerular lesion, hypercellularity and glomeruloselerosis increased gradually.Conclusion:With the increase of the severity of TIL. the condition of IgAN patients became worse .TIL may be one of the key factors for the prognosis of IgAN.
出处
《中国中西医结合肾病杂志》
2003年第10期589-591,共3页
Chinese Journal of Integrated Traditional and Western Nephrology
