中风高危患者化疗与中风发生因素分析

Analysis of Pathogen Factors and Chemotherapy of High Danger Stroke

目的 探讨中风高危患者化疗中中风发生的影响因素及防治措施。 方法 采用回顾分析法 ,对 2 0 0 0年元月至今 ,我科收治的 15例肿瘤伴中风高危住院化疗患者 ,中风发生与相关因素、及其不同预防用药方法的关系进行分析。 结果 15例中有 7例发生中风 ,5例在化疗后骨髓抑制恢复 ,血小板在 4 0 0× 10 9/ml以上时出现。 2例因治疗中长期卧床并有脱水而发生。中风发生与预防用药方法明显相关 ,在化疗中及化疗后依据血小析数量变化用阿司匹林预防治疗的无 1例发生中风 ,中风者均为血小板在化疗后回升至 30 0× 10 9/ml以上未再用阿司匹林预防治疗的。 结论 肿瘤伴中风高危化疗患者中风发生与化疗所至的血液动力学改变和血小板反跳性增高有关。

Objective to explore the factors and prevention measures of treating stroke. Methods retrospectively analyze 15 cases chemotheray patients with tumour complicated with stroke from 2000.1～2003.1 analyze the pathogenesis of stroke and its related factors and different prevention medication.Results among 15 cases, 7cases occured stroke, 5 cases bone marrow inhibition recovered after chemotherapy, blood platelet appeared at 400×10 9/ml, 2 cases occured due to long time bed stridden and dehydration during treatment. The stroke occurance is obviously related to prevention medication method. Not one case occured stroke among the cases treated by Asprin used according to the change of blood platelet amount. Stroke occured to those whose blood platelet at 300×10 9/ml and use Asprin after Chemotherapy.Conclusion Stroke occurence and the blood kinetics change are related to platelet rebouncing increase. Paying attention to the change of blood kinetics and adding small dosage Asprin according to the change of playtelet amount can effectively prevent it