冠状动脉搭桥术后再狭窄与反义基因的治疗

Restenosis after Coronary Bypass Grafting and Therapy of Antisense Gene

冠状动脉搭桥手术失败的主要原因是静脉移植物的再狭窄。其中心环节是血管平滑肌细胞(VSMC)增生。抑制VSMC的增生以预防静脉移植物的再狭窄是目前心血管研究的热点。本文就反义基因预防静脉移植物再狭窄的原理、优点、反义核酸的设计、反义治疗中必须考虑的问题进行阐述 。

Saphenous vein graft occlusion is a main reason for the failure of coronary bypass grafting.Vascular smooth muscle cell(VSMC)hyperplasis is a pivotal component of this pathobiology.it is a hot pog that VSMC proliferation is inhibited in order to prevent the restenosis of vein grafts.In this study,we discussed the principles,virtues,antisense oligodioxynucleotides' design,relative problems about inhibiting to the restenosis of vein grafts by antisense gene so that we investingate an effective method to prohibite restenosis after coronary bypass grafting.