摘要
目的 :探讨感冒一小时胶囊中黄芩苷在正常和发热大鼠体内的代谢动力学。方法 :采用高效液相技术分别测定正常大鼠和干酵母致发热大鼠血浆中黄芩苷的含量 ,使用 3P87软件处理黄芩苷的时量数据 ,计算各药代动力学参数。结果 :在正常和发热大鼠体内 ,黄芩苷的达峰时间分别为 9.46± 1.69h和 7.2 0± 2 .74h( p =0 .12 ) ) ,峰值血药浓度分别为 1.44± 0 .3 9μg/ml和 1.0 9± 0 .44 μg/ml( p =0 .2 1) ,t1/ 2 (ke)分别长达 10 .89± 5 .87h和 16.60± 2 0 .88h ,t1/ 2 (ka)分别为 3 .85± 0 .94和 2 .3 5± 1.48(p =0 .0 9) ,CL/F值分别为 2 2 .12± 5 .3 7(mg/kg) /h( μg/ml)和 3 8.3 8± 2 2 .99(mg/kg) /h/( μg/ml) ( p =0 .16) ,AUC(O T)值分别为 2 .68± 5 .81( μg/ml) h和 16.12± 4.91( μg/ml) h(P <0 .0 5 )。结论 :发热明显降低黄芩苷在体内的AUC(O T) ,有加快黄芩苷吸收和消除的趋势。
Ojbective: To explore pharmacokinetics of baicalin in Ganmao Yixiaoshi in normal and febrile rats. Methods: The levels of baicalin in plasma were measured through HPLC and secondary parameters were obtained by fitting the dose-time data of baicalin making use of 3P87 program. Results: In normal and febrile rats, the plasma concentration of baicalin was peaked at 9.46±1.69h vs. 7.20±2.74h (P=0.12) with a level of 1.44±0.39μg/ml vs. 1.09±0.44μg/ml (P=0.21), and the t 1/2 (ke), t 1/2 (ka), CL/F and AUC(O T) of baicalin was 10.89±5.87h vs. 16.60±20.88h, 3.85±0.94 vs. 2.35±1.48 (P=0.09), 22.12±5.37(mg/kg)/h/(ug/ml) vs. 38.38±22.99(mg/kg)/h/(μg/ml) (P=0.16) and 24.68±5.81(μg/ml)*h vs. 16.12±4.91(μg/ml)*h (P<0.05), respectively. Conclusion: AUC (O-T) of baicalin was cut remarkably in febrile rats and its absorption and clearance had a tendency to accelerate.
出处
《中药药理与临床》
CAS
CSCD
2003年第4期34-37,共4页
Pharmacology and Clinics of Chinese Materia Medica
基金
清华大学科技开发项目资助 (2 0 0 2 1 62 )
