氟西汀与氯丙咪嗪治疗强迫症的临床对照研究

Clinical Study of Fluoxetine and Clomipramine in the Treatment of Obsessive-Compulsive Disorder

目的 探讨氟西汀治疗强迫症的临床疗效和副反应。方法 6 0例强迫症患者随机分为两组 :(1)A组 :30例 ;(2 )B组 :30例。A组采用氟西汀口服 ;B组采用氯丙咪嗪口服。两组疗程均为 8周。两组治疗后 ,采用Yale -Brown强迫量表、副反应量表和临床疗效评定标准 ,分别评定疗效和副反应。结果 A组与B组疗效相似。显效率 (痊愈 +显著进步 ) :A组为 5 0 .0 %(15 / 30 ) ,B组为 5 3.3%(16 / 30 ) ,两组相比较 ,无显著性差异 (P >0 .0 5 ) ;Yale Brown强迫量表减分率 :两组治疗、后相比较 ,无显著性差异 (P >0 .0 5 )。副反应 :A组较B组少、且轻微 ,两组相比较 ,有显著性差异 (P <0 .0 5 )。结论 氟西汀与氯丙咪嗪对强迫症均有较好的疗效 ,但氟西汀具有日服剂量小、给药方法简便、副反应轻微等优点。

Objective To investigate the efficacy and the side effects of fluoxetine in the treatmeat of obsessive-compulsive disorder(OCD).Methods Sixty patients who met the CCMD-3 for OCD were involved in this study.Fluoxetine efficacy in treatment of OCD were assessed with Y-BOCS and the side effects of fluoxetine were evaluated with Treatment Emergent Symptom Scale(TESS)compared with clomipramine.Results The therapeutic efficacy in fluoxetine group was similar to that in clomipramine(P>0.05).However,the side effects of fluoxetine were lighter than that of clomipramine.Conclusion The results indicate that both fluoxetine and clomipramine is effective in the treatment of OCD,but fluoxetine shows more advantage for its convenient administration and low daily dosage and its side effects were lighter.