摘要
rBS 与 WC 联合免疫比单纯免疫效果好;小鼠或家兔的免疫间隔适当缩短未见影响免疫保护力:小鼠一次大剂量口服疫苗后可获良好保护。rBS-WC 抗原、吸附霍乱类毒素疫苗(上海苗)和吸附霍乱疫苗(武汉苗)经家兔肌肉免疫,武汉苗未见抗 CT 反应,对 CT 攻击无保护,对 Eltor(小川)活菌攻击保护较弱;上海苗抗 CT 反应比 rBS-WC 低。家兔口服 rBS-WC 半年后,抗 CT 及杀弧菌抗体维持较高水平,显示其动物免疫的持久性。
The authors reported that the immune efficacy of combined administration of rBS and WC cholora vaccines was better than that of single administration of each vaccine.Proper shortening of the inter- val of immunzation to mice or rabbits was not seemed to influence immunoprotection.Good protection effect was observed after the oral rBS-WC vaccine in high dosage was administered to mice.rBS-WC antigen,ad- sorbed cholera toxoid and adsorbed cholera vaccine were administered to rabbits intramuscularly.No CT antibody response or protection to challenge of CT was observed after adminstration with absorbed cholera vaccine,and the protection of the vaccine to the challenge of Eltor live bacterium was weak.The CT antibody response of adsorbed cholera toxoid was lower than that of rBS-WC vaccine still kept at higher level.It indi- cated that rBS-WC vaccine showed good immune persistence.
