期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

膜融合脂质体作为疫苗载体的研究进展 被引量：3

Development of membrane fusogenic lipesomes as the vector of vaccine
下载PDF
导出
摘要 目的　对病毒 脂质体融合形成的膜融合脂质体的融合机制、制备方法、抗原导入、抗原呈递及其作为疫苗导入载体的研究进展做一分析和总结。方法　总结近几年来有关方面的文献。结果　膜融合脂质体可以将抗原导入到细胞质中 ,并诱发强烈的CTL反应。膜融合脂质体的融合为融合蛋白的空间结构发生变化所致。结论　膜融合脂质体是一种非常有发展前景的抗原导入载体。
作者 李强 金一 崔福德
机构地区 浙江大学药学院药剂教研室 沈阳药科大学药剂教研室
出处 《中国药学杂志》 CAS CSCD 北大核心 2003年第10期734-737,共4页 Chinese Pharmaceutical Journal
关键词 膜融合脂质体 疫苗载体 制备 融合机制 抗原导入
分类号 R392-33 [医药卫生—免疫学]
  • 相关文献

参考文献31

  • 1胡英,金一,王华,李敏伟.阳离子膜融合脂质体介导反义寡核苷酸在Hela细胞中的转染实验研究[J].药学学报,2002,37(11):892-896. 被引量：8
  • 2Lamb RA. Paramyxovirus fusion: a hypothesis for changes[J ].Virology, 1993,197( 1 ) : 1.
  • 3Hughson FM. Structural characterization of viral fusion protein[J ]. Curr Biol, 1995,5(3) :265.
  • 4Ruigrok RW, Barge A, Durrer P, et al. Membrane interaction of influenza virus M1 protein[J]. Virology,2000,267(2) :289.
  • 5Takimoto T, Taylor GL, Crennell SJ, et al. Crystallization of newcastle disease virus heamagglutinin-neuraminidase glycoprotein[J ]. Virology ,2000,270( 1 ) .'208.
  • 6Cameiro FA, Ferradosa AS, Da Poian AT. Low pH-induced conformational changes in Ve. sicular stomatitis virus glycoprotein involve dramatic structure reorganization[J ]. J Biol Chem ,2001,276(1):62.
  • 7Ramalho-Santos J, Lima MC, Nir S. Partial fusion activity of influenza virus toward liposomes and erythrocyte ghosts is distinct from viral inactivation[ J ]. J Biol Chem, 1996,271 (39) : 23902.
  • 8Gunter-Ausborn S, Schoen P, Bartoldus I, et al. Role of hemagglutinin surface density in the initial stages of influenza virus fusion., lack of evidence for cooperativity[J ]. J Virol,2000,74(6) :2714.
  • 9Tomasi M, Baiocchi M, Moscufo N, et al. Mild proteolysis inducea a ready-to-fuse state on Sendai virus envelope[J]. FEBS Later, 1998,423(3): 286.
  • 10Stone HJ, Morrison TG. Detection of an interaction between the HN and F proteins in Newcastle disease virus-infected cells[J]. J Virol, 1997,71 (9) :6287.

二级参考文献11

  • 1[1]Son KK, Tkach D, Hall KJ. Efficient in vivo gene delivery by the negatively charged complexes of cationic liposomes and plasmid DNA [J]. Biochim Biophy Act, 2000,29(1-2):6-10.
  • 2[2]Mario CF, Nigel CP. Major limitations in the use of cationic liposomes for DNA delivery [J]. Int J Pharm, 1998,162(1-2):159-170.
  • 3[3]Nakanishi M, Uchida T, Sugawa H, et al. Efficient introduction of contents of liposomes into cells using HVJ (Sendai virus) [J]. Exp Cell Res, 1985,159(2):399-409.
  • 4[4]Mizuguchi H, Nakanishi M, Nakanishi T, et al. Application of fusogenic liposomes containing fragment A of diphtheria toxin to cancer therapy [J]. Br J Cancer, 1996,73(4):472-476.
  • 5[5]Mizuguchi H, Nakanishi T, Kondoh M, et al. Fusion of Sendai virus with liposome depends on only F protein, but not HN protein [J]. Virus Res, 1999,59(2):191-201.
  • 6[6]Dzau VJ, Mann MJ, Morishita R, et al. Fusogenic viral liposome for gene therapy in cardiovascular diseases [J]. Proc Natl Acad Sci USA, 1996,93(21):1421-1425.
  • 7[7]Nakanishi M, Mizuguchi H, Ashihara K, et al. Gene transfer vectors based on Sendai virus [J]. J Controlled Release, 1998,54(1):61-68.
  • 8[8]Gao X, Huang L. A novel cationic liposome reagent for efficiency transfection of mannalian cells [J]. Biochem Biophys Res Common, 1991,179(1):280-285.
  • 9[9]Lee KD, Nir S, Papahadjopoulos D. Quantitative analysis of liposome-cell interactions in vitro: rate constants of binding and endocytosis with suspension and adherent J774 cells and human monocytes [J]. Biochemistry, 1993,32(3):889-899.
  • 10[10]Mizuguchi H, Nakagawa T, Nakanishi M, et al. Efficient gene transfer into mannalian cells using fusogenic liposome [J]. Biochem Biophys Res Common, 1996,218(1):402-407.

共引文献7

同被引文献36

  • 1易学文,吴霞.免疫脂质体的研究进展[J].四川理工学院学报（自然科学版）,2004,17(3):133-136. 被引量：4
  • 2吴小宁,王军,欧阳五庆.脂质体在生物领域内的研究进展[J].动物医学进展,2005,26(6):44-47. 被引量：3
  • 3孙波,杨骅,李兆申,屠振兴,龚燕芳,杜奕奇.幽门螺杆菌UreB-NAP-HpaA三价DNA疫苗的构建及免疫原性初步研究[J].第二军医大学学报,2005,26(6):636-638. 被引量：3
  • 4丁玉玲,马淑贤,卢秀荣,王海波,霍玉书.人参皂甙脂质体（GSL）的研制[J].中国药学杂志,1995,30(7):414-417. 被引量：35
  • 5穆筱梅.脂质体在化妆品中的应用[J].广东化工,2006,33(2):20-21. 被引量：5
  • 6Fabani M M,Gargini R,Taira M C,et al.Study of in vitro stability of liposomes and in vivo antibody response to antigen associated with liposomes containing GM1 after oral and subcutaneous immunization.J Liposome Res,2002,12 (1 ～2):13～27
  • 7Ninomiya A,Ogasawara K,Kajino K,et al.Intranasal administration of a synthetic peptide vaccine encapsulated in liposome together with an anti-CD40 antibody induces protective immunity against influenza A virus in mice.Vaccine,2002,20 (25 ～26):3123 ～3129
  • 8Lee C K,Weltzin R,Thomas W D,et al.Oral immunization with recombinant Helicobacter pyloriurease induces secretory IgA antibodies and protects mice from challenge with Helicobacter felis.J Infect Dis,1995,172 (2):161 ～172
  • 9Ermak T H,Giannasca P J,Nichols R,et al.Immunization of mice with urease vaccine affords protection agaist Helicobacter pylori infection in the absence of antibodies and is mediated by MHC class Ⅱ restricted responses.J Exp Med,1998,188 (10):2277～2288
  • 10Stuttin P,Wilson J,Kosaka T,et al.Therapeutic immunization agaist Helicobacter pylori infection in the absence of antibodies,Immunol Cell Biol,2000,78 (1):28～30

引证文献3

二级引证文献5

中国药学杂志
2003年 第10期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部