绝经后骨质疏松症合并四肢骨折临床初探

Primary clinical study on postmenopausal osteoporosis combined with extremity fracture

目的 :研究绝经后骨质疏松症与四肢骨折的关系 ,为防治绝经后四肢骨质疏松性骨折提供有用的数据和预防措施。方法 :测量绝经后骨质疏松症患者骨密度值和雌二醇水平 ,统计近 8年来收集的 978例绝经后四肢骨质疏松性骨折病例的年龄、骨折部位和致伤原因的分布规律及其与骨密度和雌二醇的相关性。结果 :年龄与骨密度、雌二醇均呈显著负相关 ,骨密度与雌二醇呈显著正相关 (P <0 .0 1) ;绝经后四肢骨质疏松性骨折患者随着年龄的增加发病率也增加 ;跌倒是绝经后四肢骨质疏松性骨折的主要原因 ;骨折组与非骨折组骨密度、雌二醇比较 ,差异有显著性 (P <0 .0 1)。结论 :骨密度值和雌二醇水平下降是绝经后四肢骨质疏松性骨折重要的内在因素 ,但外在因素也不可忽视。

To provided useful data and measures for prevention and cure of postmenopausal extremity osteoporosis fracture,the relation between postmenopausal osteoporosis and extremity fracture was studied.Methods:BMD、E 2of postmenopausal osteoporosis was measured,the 978 cases of extremity fracture were reviewed from 1995 to 2002.The age,fracture position and injuy cause as well as were the relation between postmenopausal osteoporosis and it′s BMD、E 2were analysed.Results:Significant negative correlation between the age and serum level of E 2as well of E 2(P<0.01),significant positive correlation between BMD and serum level of E 2(P<0.01);the cases of postmenopausal limbless osteoporosis fracture increased along with the increasing of the age;injury from fall was the main cause,the difference of BMD,E 2between fracture group and non-fracture group was significant(P<0.01).Conclusion:The decline of BMD、E 2is the important internal factor and the external factors is essential.