脂肪肝病人血液流变学的临床观察

HEMORHEOLOGY CLINICAL OBSERVATION OF FATTY LIVER PATIENT

目的 :目前临床对脂肪肝病人的诊断 ,实验室没有理想的检测手段。我们对临床确诊的脂肪肝病人 ,同时伴有甘油三酯增高者 86例 ,对血液流变学各参数的变化进行了比较 ,以观察临床对脂肪肝诊断的实用价值。方法 :取空腹静脉血 3mL注入肝素抗凝管混合 ,先测全血粘度 ,然后分离血浆测其血浆粘度。甘油三酯取空腹肘静脉血 2mL ,分离血清进行检测。结果 :86例脂肪肝病人全血粘度 :高切、低切、红细胞电泳时间及甘油三酯同时增高者 6 1例 ,占 70 .9%。全血粘度 :高切、中切、低切 ,血浆粘度 ,全血还原粘度 ,红细胞聚集指数 ,红细胞电泳时间 ,甘油三酯同时增高者 19例 ,占 2 2 .1%。单纯全血粘度低切增高者 6例 ,占 7%。结论 :脂肪肝病人血液流变学各参数的影响主要是全血粘度及红细胞电泳时间有明显的改变 ,甘油三酯的增高对血浆粘度及全血还原粘度影响不太明显。

Objective: There is no ideal test method to diagnose fatty liver. We compare the hemorheology parameter of 86 clincal cases with triglyceride increase, who were diagnosed fatty liver. In order to observe the practical value of fatty liver diagnosis. Methods: Take 3mL venous blood on an empty stomach. And mix it into heparin test tube; first measure blood viscosity, then separate plasma and measure plamsa viscosity. Take 2mL blood from patient's elbow vein to separate serum,and test trigltceride. Result: There are 61 patients(70.9%) demonstrated high shear, low shear blood viscosity and RBC electrophoresis time simultaneous increase. 19 patients(22.1%) showed high shear, medium shear, low shear, plasma viscosity,reduced viscosity, erythrocyte aggregation index, RBC electrophoresis time, triglyceride increase simultaneously, 6 patients showed low shear whole blood viscocity increase purely . Conclusions: Major in Hemorheology parameters of Fatty liver patients is obvious change of reduced viscocity and RBC electrophoresis time, increased triglyceride does not affect whole blood viscocity and plasma viscocity obviously, which can be used as auxiliary index for clinical fatty liver patients diagnosis.