儿童急性白血病血清IL6、IL8水平测定的意义

THE CLINICAL SIGNIFICANCE OF SERUM INTERLEUKIN-6、 INTERLEUKIN-8 LEVELS IN CHILDHOOD ACUTE LEUKEMIA

为探讨血清IL 6、IL 8水平变化与儿童急性白血病 (AL)发生、发展及预后的关系。采用夹心酶联免疫吸附法检测 6 8例儿童AL患者血清IL 6、IL 8水平。结果 ,儿童AL患者血清IL 6、IL 8水平愈高 ;发生出血愈严重 ,血清IL 6水平愈高 ,但血清IL 8水平在轻、中度出血时显著升高 ,而发生严重出血倾向时并不升高 ;当儿童AL治疗获缓解时 ,血清IL 6、IL 8水平逐渐下降 ,完全缓解时 ,接近于正常水平。结果表明 :血清IL 6、IL 8的异常表达在儿童AL的发生、发展中可能起着一定作用 ,检测儿童AL血清IL 6、IL 8水平可能作为判断疗效。

Objective: To explore the correlation between serum interleukin-6(IL-6)? Interleukin-8(IL-8) levels and the genesis? development and prognosis of childhood acute leukemia(AL). Method: Serum IL-6?IL-8 lvevls were measured in 68 children with AL by sandwich enzyme linked immunosorbent assay(ELISA). Results: The level of serum IL-6?IL-8 increased significantly in childhood AL than in normal controls. In the course of treatment, the more serious the infectionwas, thh higher level of serum IL-6?IL-8 was measured. And the more serious the hemorrhage was, the higher level of serum IL-6 was measured, too. The level of serum IL-8 increased significantly in time of slight or moderate hemorrhage, while it didn′t increase in time of critical hemorrhage. The level of serum IL-6?IL-8 declined gradually in responding patients after therapy, and there were no differences between CR cases and controls. Conclusion: The abnormal expression of serum IL-6?IL-8 may play some role in the genesis and development of childhood AL. The level of serum IL-6、IL-8 may be used as a parameter of forcasing the curative effec、prognosis and relapse in childhood AL.