原发性高血压患者偶联因子6水平及其与内皮素、心钠肽的关系

Plasma coupling factor 6 level and its relationships with atrial natriuretic peptide and endothelin in patients with essential hypertension

目的:研究高血压患者血浆偶联因子6(couplingfactor6,CF6)水平及与心钠肽(atrialnatriureticpeptide,ANP)、内皮素的关系,探讨原发性高血压的发病机制,为临床原发性高血压的治疗及实施康复干预提供理论依据。方法:选取血清肌酐在正常范围内、未发生心脑血管事件的门诊原发性高血压患者50例,健康查体者23例作为对照,应用酶联放射免疫吸附分析入选者空腹血浆CF6以及心钠肽、内皮素水平。其中CF6数据经对数转换后进行统计学分析。结果:高血压组血浆CF6水平明显低于对照组犤(118.3±1.4),(164.5±1.2)ng/L,t=4.30,P<0.001犦,男女两性之间CF6水平差异没有显著性意义。高血压组内皮素水平显著高于对照组犤(67±21),(48±22)ng/L,t=3.49,P<0.001犦。但两组中,CF6水平与内皮素水平不相关(两组相关系数分别为0.073,-0.056,P>0.05)。高血压组心钠肽水平高于对照组犤(115±38),(96±33)ng/L,(t=2.11,P<0.05)犦。但高血压组和对照组中,CF6水平与心钠肽水平不相关(两组相关系数分别为-0.045,-0.27,P>0.05)。结论:未中断治疗的高血压患者的CF6水平低于正常对照,其水平与内皮素、心钠肽不相关。

AIM:To study the plasma coupling factor 6(CF6) level and its relationships wit h atrial natriuretic peptide(ANP) and endothelin in essential hypertension to ma nifest the pathogenesis of essential hypertension,and provide theoretical eviden ce for treatment of clinical essential hypertension and practice of rehabilitati on intervention. METHODS:50 outpatients suffering from essential hypertension whose serum creat inine was in normal range without history of cardiac events or stroke,23 cases o f healthy control were enrolled in the study.Fasting blood sample was drawn for analysis of level of CF6, ANP and endothelin by using enzyme-linked radioimmuno sorbent assay.The data of CF6 were logarithmically transformed before statistic analysis. RESULTS:The CF6 level in hypertension group was significantly lower than that in control group[(118.3±1.4),(164.5±1.2)ng/L,t=4.30,P< 0.001],while ther e was no obvious difference between genders in both groups. The endothelin level was significantly higher than that in control group[(67±21),(48±22)ng/L,t=3 .49,P< 0.001]. The level of CF6 was not correlated to that of endothelin in bot h group(r=0.073,-0.056 respectively, P >0.05). ANP level in hypertension group was significantly higher than that in control group[(115±38) ,(96±33)ng/L,t=2. 11,P< 0.05].The CF6 level was not correlated to ANP level in both group(-0.045, -0.27 respectively,P >0.05).