原发性甲状腺淋巴瘤组织类型与临床病理学的关系

THE CORRELATION OF HISTOLOGICAL TYPES AND CLINICOPATHOLOGICAL FINDINGS OF PRIMARY THYROID LYMPHOMA

目的 :分析甲状腺淋巴瘤的类型及与临床的关系。方法 :采用 WHO2 0 0 0年淋巴肿瘤分类方案 ,光镜形态结合免疫组织化学结果对肿瘤进行分类 ,根据类型分为高度和低度恶性两组 ,结合临床和其他病理学所见进行分析。结果 :2 2例中 MZBL 6例和 FCL 1例 ;DL BCL1 5例。与低度恶性组比较高度恶性组更常见肿瘤浸润周围组织 ,临床分期较晚 (P<0 .0 5和 P<0 .0 1 )。肿瘤周围组织呈淋巴细胞性甲状腺炎常见 (1 7/ 2 2 ,77% )。结论 :甲状腺淋巴瘤的类型是异质性 ,有不同的临床和病理学表现 。

Objective:To analyze the correlation between the histological types and clinicopathology of lymphoma of thyroid.Methods:The histological types were determined by using the 2000 WHO classification for lymphoma and combining the results of microscopic observation and immunohistochemistry, They were divided into two groups, low grade and high grade. The correlation of clinicopathological findings and the histological types were analyzed. Results:There were 7 cases in low grade group, including MZBL 6 cases and FCL 1 case; 15 cases of DLBCL in high grade group. In high grade, the surrounding tissue infiltration were more common and the clinical staging were later comparing with low grade( P <0.05, P <0.01 respectively). In addition, Hashimoto's disease was found in most of the cases(17/22,77 %).Conclusion:Primary thyroid lymphoma is a heterogeneous disease,with different clinical and pathological presents. Applying MALT lymphoma to designate all thyroid lymphoma will lead physicians misunderstanding.