活性人工皮肤的骨架——一种新型胶原复合膜的制备及性能研究

Preparation and study of scaffold of active artificial skin-A new collagen composite membrane

以从成年牛筋腱中提取的I型胶原、甲壳糖、透明质酸(HA雪为基材,采用冷冻干燥、戊二醛交联的方法,制备一种新型的胶原复合膜。通过生理盐水耐受力测试,强度检测,比较交联前后的体外降解等研究新型胶原复合膜的性能。结果表明:含甲壳糖8%,10%的胶原复合膜是较理想的活性人工皮肤骨架材料。

A new collagen composite membrane made of I collagen- chitosan and hyaluronic acid (2.5%) was developed by freezing drying and crosslinking. The endurance in physiological aline solution- mechanical characteristics and time of vitro degradation showed the property of it. The results indicated that the collagen composite membrane with the concentration 8%- 10% of chitosan are the better scaffold of active artificial skin.