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Wnt信号通路与肿瘤侵袭转移的关系 被引量：1

Relationship between the Wnt signaling pathways and tumor invasion and metastasis
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摘要 近年来的研究发现 ,Wnt β catenin信号通路与肿瘤侵袭转移的相关事件如癌细胞的迁移粘附、细胞外基质的降解及肿瘤的血管生成密切相关。Wnt信号还能激活Wnt Ca2 + 、Wnt JNK等非正规通路 ,与人类肿瘤的侵袭转移也有一定关系。另外 ,Wnt通路还可通过与细胞内其他信号通路如K ras、RTK及ILK介导的信号通路相互作用 。
作者 蔡秋凤 欧阳高亮 鲍仕登
机构地区 厦门大学细胞生物学与肿瘤细胞工程教育部重点实验室
出处 《国外医学（肿瘤学分册）》 2003年第5期326-329,共4页 Foreign Medical Sciences (Cancer Section)
基金 国家自然科学基金资助项目 ( 3 0 170 463 )
关键词 WNT信号通路 肿瘤 侵袭 转移
分类号 R730.2 [医药卫生—肿瘤]
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参考文献21

  • 1Cagatay T Ozturk M.P53 mutation as a source of aberrant β-carenin accumulation in cancer cells[J].Oncogene,2002,21(52):7971-7980.
  • 2Chen RH, Ding WV, McCormick F. Wnt si8gnaling to β-catenin involves two interactive components: Glycogen synthase kinase-3β inhibition and activation of protein kinase C[J]. J Biol Chem, 2000, 275(23): 17894-17899.
  • 3Cagatay T, Ozturk M. P53 mutation as a source of aberrant β-catenin acctmaulation in cancer cells[J]. Oncogeae, 2002, 21(52):7971-7980.
  • 4Egeblad M, Werb Z. New functions for the matrix metalloproteinases in cancer progression[J]. Nat Rev Cancer, 2002, 2(3): 161-174.
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  • 6Miller JR, Hocldng AM, Brown JD, et al. Mechanism and function of signal transduction by the Wnt/β-catenin and Wnt/Ca^2+ pathways [J]. Oncogme, 1999, 18(55): 7860-7872.
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同被引文献25

  • 1何小平,朱人敏.肿瘤血管生成与抗肿瘤血管生成基因治疗的进展[J].医学研究生学报,2005,18(6):559-563. 被引量：15
  • 2Wehrli M,Dougan ST,Caldwell K,et al.Arrow encodes an LDL-receptor-related protein essential for Wingless signalling[J].Nature,2000,407 (6803):527-530.
  • 3Heisenberg CP.Wnt signalling:refocusing on Strabismus[J].Curr Biol,2002,12(19):R657-659.
  • 4Kikuchi A,Kishida S,Yamamoto H.Regulation of Wnt signaling by protein-protein interaction and post-translational modifications[J].Exp Mol Med,2006,38(1):1-10.
  • 5DasGupta R,Kaykas A,Moon RT,et al.Functional genomic analysis of the Wnt-wingless signaling pathway[J].Science,2005,308 (5723):826-833.
  • 6Mao B,Niehrs C.Kremen2 modulates Dickkopf2 activity during-Wnt/LRP6 signaling[J].Gene,2003,302 (1-2):179-183.
  • 7Amit S,Hatzubai A,Birman Y,et al.Axin-mediated CKI phosphorylation of beta-catenin at Ser 45:a molecular switch for the Wnt pathway[J].Genes Dev,2002,16(9):1066-1076.
  • 8Xing Y,Clements WK,Kimelman D,et al.Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex[J].Genes Dev,2003,17 (22):2753-2764.
  • 9Church VL,Francis-West P.Wnt signalling during limb development[J].Int J Dev Biol,2002,46(7):927-936.
  • 10Kispert A,Vainio S,McMahon AP.Wnt-4 is a mesenchymal signal for epithelial transformation of metanephric mesenchyme in the developing kidney[J].Development,1998,125 (21):4225-4234.

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二级引证文献5

国外医学（肿瘤学分册）
2003年 第5期

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