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癌基因Stat3与肿瘤治疗 被引量:2

Stat3 signaling in the treatment of cancer
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摘要 Stat3信号传导通路接受生长因子、细胞因子等细胞外信号刺激 ,作用于细胞核内特异的DNA片段 ,调控靶基因如cyclinD1与bcl x等的转录 ,直接影响细胞的增殖、分化与凋亡。研究结果显示Stat3蛋白异常激活与多种恶性肿瘤发生、发展密切相关 ,被定义为癌基因 ,目前已有学者以Stat3为靶点进行肿瘤治疗研究 ,取得了初步结果 ,但有关Stat3的详细作用机制尚未明确 。
作者 马向涛
出处 《国外医学(肿瘤学分册)》 2003年第5期330-332,共3页 Foreign Medical Sciences (Cancer Section)
基金 国家自然科学基金资助项目 ( 3 0 2 712 69)
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参考文献17

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同被引文献24

  • 1邱阳,刘越坚,郭莉,单路娟,郭慧淑.流式细胞术检测急性白血病P-糖蛋白、多药耐药相关蛋白及bcl-2的临床意义[J].白血病.淋巴瘤,2008,17(2). 被引量:3
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  • 5Alas S, Bonavida B. Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulalion of Bcl-2 and sensitization to cytotoxic drugs. Cancer Res, 2001, 61: 5137-5144.
  • 6Bowman T, Garcia R, Turkson J, et al. STATs in oncogenesis. Oncogene, 2000, 19: 2474-2488.
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