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癌基因Stat3与肿瘤治疗 被引量：2

Stat3 signaling in the treatment of cancer
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摘要 Stat3信号传导通路接受生长因子、细胞因子等细胞外信号刺激 ,作用于细胞核内特异的DNA片段 ,调控靶基因如cyclinD1与bcl x等的转录 ,直接影响细胞的增殖、分化与凋亡。研究结果显示Stat3蛋白异常激活与多种恶性肿瘤发生、发展密切相关 ,被定义为癌基因 ,目前已有学者以Stat3为靶点进行肿瘤治疗研究 ,取得了初步结果 ,但有关Stat3的详细作用机制尚未明确 。
作者 马向涛
机构地区 北京大学人民医院外二科外科肿瘤研究室
出处 《国外医学（肿瘤学分册）》 2003年第5期330-332,共3页 Foreign Medical Sciences (Cancer Section)
基金 国家自然科学基金资助项目 ( 3 0 2 712 69)
关键词 癌基因 STAT3 肿瘤 治疗
分类号 R730.5 [医药卫生—肿瘤]
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参考文献17

  • 1Bromberg JF, Wrzeszczynska MH, Devgan G, et al. Stat3 as an oneogene [J]. Cell, 1999, 98(3): 295-303.
  • 2Levy DE, Damell JE Jr. Stats: transcriptional control and biological impact [J]. Nat Rev Mol Cell Biol, 2002, 3(9): 651-662.
  • 3Bownmn T, Garcia R, Turk.son J, et al. STATs in oncogenesis [J ]. Oncogene, 2000, 9(21): 2474-2488.
  • 4Galderisi U, Cascino A, Giordano A. Antisense oligonucleotides as therapeutic agents [J]. J Cell Physiol, 1999, 181(2): 251-257.
  • 5Grandis JR, Drenning SD, Zeng Q, et al. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo [J]. Proc Natl Acad Sci USA, 2000, 97(8) : 4227-4232.
  • 6Zhang J, Shen B, Li Y, et al. STAT3 exerts two-way regulation in the biological effects of IL-6 in M1 leukemia cells [ J ]. Leuk Res, 2001, 25(6): 463-472.
  • 7Huang JS, Guh JY, Hung WC, et al. Role of the Janus kinase (JAK)/signal transducers and activators of transcription (STAT) cascade in advanced glycation end-product-induced cellular mitogenesis in NRK-49F cells [J]. Biochem J, 1999, 342(pt 1) : 231-238.
  • 8Smithgall TE, Briggs SD, Schreiner S, et al. Control of myeloid differentiation and survival by Stats [J ]. Oncogene, 2000, 19 (21) :2612-2618.
  • 9Catlett Faleone R, Landowski TH, Oshiro MM, et al. Constitutive activation of Star3 signaling eotffers resistance to apoptosis in human U266 myelorna cells [J]. Immunity, 1999, 10(1): 105-115.
  • 10Burke WM, Jin X, Lin HJ, et al. Inhibition of eonstitutivdy active Star3 suppresses growth of human ovarian and breast cancer cells [J]. Oneogene, 2001, 20(55): 7925-7934.

同被引文献24

  • 1邱阳,刘越坚,郭莉,单路娟,郭慧淑.流式细胞术检测急性白血病P-糖蛋白、多药耐药相关蛋白及bcl-2的临床意义[J].白血病．淋巴瘤,2008,17(2). 被引量：3
  • 2Simonian PL, Grillot DA, Nunez G. Bcl-2 and Bcl-XL can differentially block chemotherapy-induced cell death. Blood, 1997, 90: 1208-1216.
  • 3Nielsen M, Kaestel CG, Eriksen KW, et al. Inhibition of constitutively activated Star3 correlates with altered Bcl-2/Bax expression and induction of apoptosis in mycosis fungoides tumor cells. Leukemia, 1999, 13: 735-738.
  • 4Stephanou A, Brar BK, Knight RA, et ah Opposing actions of STAT-1 and STAT-3 on the Bct-2 and Bcl-x promoters. Cell Death Differ, 2000, 7: 329-330.
  • 5Alas S, Bonavida B. Rituximab inactivates signal transducer and activation of transcription 3 (STAT3) activity in B-non-Hodgkin's lymphoma through inhibition of the interleukin 10 autocrine/paracrine loop and results in down-regulalion of Bcl-2 and sensitization to cytotoxic drugs. Cancer Res, 2001, 61: 5137-5144.
  • 6Bowman T, Garcia R, Turkson J, et al. STATs in oncogenesis. Oncogene, 2000, 19: 2474-2488.
  • 7Hirano T, Ishihara K, Hibi M. Roles of STAT3 in mediating the cell growth, differentiation and survival signals relayed through the IL-6 family of cytokine receptor. Oncogene, 2000, 19: 2548-2556.
  • 8Gao B, Shen X, Kunos G, et al. Constitutive activation of JAK-STAT3 signaling by BRCA1 in human prostate cancer cells. FEBS Let, 2001, 488: 179-184.
  • 9Garcia R, Bowman T L, Niu G, et al. Constitutive activation of Stat3 by the Src and JAK tyrosine kinases participates in growth regulation of human breast earcinoma cells. Oncogene, 2001, 20: 2499-2513.
  • 10Grandis JR, Zeng Q, Drenning SD. Epidermal growth factor receptor-mediated stat3 signaling blocks apoptosis in head and neck cancer. Laryngoscope, 2000, 110: 868-874.

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二级引证文献9

国外医学（肿瘤学分册）
2003年 第5期

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