格列齐特对老年糖尿病患者冠状动脉血流储备变化的初步观察

The effects of treatment with gliclazide on coronary flow reserve in elderly diabetic

目的 观察老年糖尿病患者冠状动脉血流储备 (coronaryflowreserve ,CFR)的变化及格列齐特治疗对糖尿病患者CFR的影响。 方法 选取 2 5例 2型糖尿病患者 ,将格列齐特治疗前患者血糖、糖化血红蛋白A1c、血脂、内皮素 1水平及CFR(应用彩色多普勒超声仪检测 )结果与 2 8例健康老年人作对照 ,并将治疗前、后的各项指标进行比较。 结果 格列齐特治疗 6个月后 ,患者的空腹血糖、早餐后 2h血糖、糖化血红蛋白A1c及内皮素 1水平较治疗前显著下降 (均为P <0 0 1) ,甘油三酯水平下降 (P <0 0 5 ) ,CFR从治疗前的 2 31± 0 4 9上升到 3 2 9± 0 4 2 (P <0 0 1)。结论 应用格列齐特治疗可改善老年糖尿病患者的CFR。

Objective In order to evaluate the coronary flow reserve (CFR) in elderly diabetic and the effects of therapy with gliclazide on CFR in these patients. Methods Twenty-five elderly diabetic and 28 healthy elderly subjects were studied. Both the levels of fast blood glucose (FBG), blood glucose 2 hours after breakfast (P2hBG), glycosylation hemoglobin A1c(HbA1c), serum total cholesterol (TC), low density lipid cholesterol (LDL-C), triglyceride (TG), endothelin-1 (ET-1), and CFR in control group were compared with those in elderly diabetic. Furthermore, comparison was made between the corresponding data in elderly diabetic pre- and post- treatment with gliclazide. Results After gliclazide treatment in elderly diabetic for 6 months, the levels of FBG, P2hBG, HbA1c, and ET-1 were obviously decreased (P<0.01, respectively), also TG were reduced (P<0.05) while the CFR were increased from 2.31±0.49 to 3.29±0.42(P<0.01). Conclusions The CFR in elderly diabetic is significantly decreased and could be effectively improved by gliclazide.