影响辛伐他汀降脂疗效的临床因素

Investigation of the Effects on Lipid - lowing Therapy of Simvastatin

目的:探讨影响辛伐他汀降脂疗效的临床因素。方法:共入选105例血清胆固醇水平未达标且服用辛伐他汀的患者,采用多因素回归分析的方法,观察了年龄、性别、剂量、体重、吸烟以及糖尿病等对辛伐他汀降脂疗效的影响。结果:血清总胆固醇和非高密度脂蛋白水平的降低与年龄呈负相关,与辛伐他汀的剂量呈正相关。结论:年龄和辛伐他汀的剂量是影响辛伐他汀的重要因素。

Objective: To study the effects on lipid - lowing therapy of simvastatin. Methods: 105 patients whose serum cholesterol concentrations didn' t reach the target level and who were taking simvastatin were enrolled. We investigated the effects of age, sex, weight, smoke, dose and diabetic mellitus on lipid - lowing therapy of simvastatin with multinomial logistic regression.Results: There are positive correlationship between the changes of serum cholesterol level and non - high density lipoprotein cholesterol concentration and age, and there are negative correlationship between simvastatin' s dose and the changes of serum cholesterol level and non -high density lipoprotein cholesterol concentration. Conclusion: Age and simvastatin's dose play important roles in the lipid - lowing therapy of simvastatin.