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β-阻滞剂可能具有抗动脉粥样硬化作用

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摘要 多项冠心病二级研究预防表明,β一阻滞剂长期治疗能够显著减少心血管病事件和降低死亡率[1~3].因此,该类药物已经成为心肌梗死后患者的常规用药(除非有禁忌证),也是治疗心绞痛的首选药物[4].β-阻滞剂有效的机制,多归咎于其能够改善心肌功能、抗高血压、抗心律失常、或减少心肌耗氧量.最近的两项研究提示,β-阻滞剂可能还有抗动脉粥样硬化作用.
作者 施仲伟
出处 《中国医药导刊》 2003年第5期349-350,共2页 Chinese Journal of Medicinal Guide
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  • 1黄铮,龚兰生,施仲伟,沈卫峰,于金德,刘伊丽.冠心病患者颈动脉粥样硬化与冠状动脉粥样硬化的关系[J].中华心血管病杂志,1996,24(3):194-196. 被引量:49
  • 2Olsson G, Wikstmnd J, WamoM I, et al. Metoprolol - induced reduction in postinfarction mortality: pooled results from five double - blind randomized trials. Eur Heart J, 1992, 13(1): 28-32.
  • 3Gottlieb SS, McCarter R J, Vogel RA. Effect of beta - blockade on mortality among high - risk and low - risk patients after myocardial infarction. New Engl J Med, 1998, 339(8) : 489 ~ 497.
  • 4Freemanfle N, Cleland J, Young P, et al. β - blockade after myocardial infarction: systemic review and meta regressian analysis. BMJ, 1999,318(7200) : 1730~ 1737.
  • 5Gihbons PJ, Chatterjee K, Daley J, et al. ACC/AHA/ACP- ASIM guidelines for the management of patients with chronic stable angina: executive summary and recommendations. Circulation, 1999, 99(21) : 2829~ 2848.
  • 6Hedblad B, Wikstrand J, Janzoa L, et al. Low - dose metoprolol CR/XL and fluvastatin slow progression of carotid intima - media thickness: main results from the β - Blocker Choleaterol - lowering Aaymptomatic Plaque Study(BCAPS). Circulation, 2001, 103(13): 1721-1726.
  • 7Wiklund O, HultheJ, Wikstrand J, et al. Effect of controlled release/extended release metoprolol on carotid intima - media thickness in patients with hyperoholesterolemia: a 3 - year randomized study. Stroke, 2002, 33(2) : 572- 577.
  • 8Oslund - Lindqvist AM, Lindqvist P, Brautigam J, et al. The effect of metoprolol on diet - induced atherosclerosis in rabbits. Arteriosclervsis, 1988, 8(1): 40-45.
  • 9Ablad B, Bjorkman JA, Gustafssaa D, et al. The role of sympathetic activity in atherogenesis: effects of β - blockade. Am Heart J, 1988, 116(1, part 2):322 ~ 327.
  • 10Salonen.rr, Salonen R. Ultrasound B - mode imaging in observational studies of atherosclerotic progression. Circulation,1993,87(3, Supgl 11 ):Ⅱ56~Ⅱ65.

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