摘要
目的 观察急性心肌梗死 (AMI)患者血清肌钙蛋白I(cTn-I)浓度的动态变化 ,探讨其与AMI近期预后的关系。方法 选择AMI患者76例 ,采用美国××公司的ACS180SE化学发光免疫系统 ,以双抗体夹心法测定cTn -I浓度 ,观察cTn-I浓度及动态变化 ,并观察住院期间心脏病变和并发症发生情况。结果 除1例外 ,其余75例AMI患者cTn-I浓度均高于正常 ,敏感性为98.7 %。有10例AMI患者cTn -I浓度持续升高时间>10d,10d后cTn -I浓度波动于 (1.50～3.11)ug/L之间。发生心衰、严重心律失常等并发症明显高于cTn -I较快恢复正常者 ,P<0.05。观察期间有30例AMI患者出现左心衰 ,cTn -I持续升高时间为 (9.47±4.70)d ,而不发生左心衰者cTn -I持续升高时间为 (6.71±1.77)d ,P<0.05。cTn-I持续升高时间在7d内住院期间无1例死亡 ,7～10d内有2例死亡 ,>10d有5例死亡 ,P<0.05。结论 cTn -I浓度持续升高 ,缓慢下降 ,为近期预后差的一个独立危险因素 ,需加强监护 。
Objective To observe the development of cTn-I of acute myocardial infarction(AMI), and evaluate its role for predicting the prognosis. Methods The concentration of cTn-I of 76 patients with AMI were detected by chemiluminescence technique. Results The concentration of cTn-I of 75patients with AMI was higher than normal value. The rising time of 10 patients lasted excess 10 days. 30 patients occurred heart failure. The rising time of cTn-I with heart failure was average 9.47±4.70 d, and 6.71±1.77d in patients without heart failure. Conclusion It could be an independent risk factor that the concentration of cTn-I continuously rise and slowly descent.
出处
《浙江临床医学》
2003年第10期734-735,共2页
Zhejiang Clinical Medical Journal
