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脆性组氨酸三联体基因与子宫颈癌关系的研究进展 被引量:2

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摘要 脆性组氨酸三联体 (FHIT)基因是近年发现的候选抑癌基因 ,是将染色体脆性位点和肿瘤相联系的第 1个分子生物学证据。FHIT异常和多种肿瘤密切相关 ,FHIT基因可能通过调控细胞周期 ,诱导细胞凋亡发挥抑制肿瘤的作用。在宫颈癌及宫颈上皮内瘤变组织中均存在FHIT基因异常表达 ,提示FHIT基因可能在宫颈癌发生发展中起重要作用。
作者 石海燕
出处 《现代妇产科进展》 CSCD 2003年第5期376-378,共3页 Progress in Obstetrics and Gynecology
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参考文献24

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同被引文献12

  • 1王国付,钦光跃,李祝尧,吴健,黄勍栋.非小细胞肺癌组织中FHIT、P53和P16蛋白的异常表达及其与临床病理的关系[J].中国癌症杂志,2004,14(4):321-324. 被引量:3
  • 2亢春彦.脆性组氨酸三联体基因与肺癌的早期预警[J].河南医学研究,2004,13(3):282-284. 被引量:1
  • 3殷德涛,董明敏.喉鳞状细胞癌中脆性组氨酸三联体基因启动子甲基化及其蛋白的表达[J].临床耳鼻咽喉科杂志,2005,19(6):253-255. 被引量:6
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  • 5Pekarsky Y, Zanesi N, Palamarchuk A, et al. Fhit from gene discovery to cancer treament and prevention[J]. Lancet Oncol,2002,3:748-754
  • 6Ozaki K, Enomoto T, Yosaino K, et al. Fhit alterations in endometrial carcinoma and hyperplasia[J] .Int J Cancer,2000,85:306-312
  • 7Segawa T, SaSagawa T, Saijoh K, et al. Clinicopathological significance of fragile histidine triad transcription protein expression in endormetrial carcinoma[J] .Clin Cancer Res,2000,6:2341-2348
  • 8Hendricks DT,Taylor R, Reed M, et al. Fhit gene expression in human ovarian, endometrial and cervical cancer cell lines [J]. Cancer Res, 1997 , 57 : 2112-2115
  • 9Hadaczek P, Gronwald J, Chosia M, et al. Fhit protein expression in endometrial cancers no correlation with histologyical grade[J] .Pol J Pathol,2001,52:199-203
  • 10Takai N, Miyazaki T, Nishida M, et al. Survivin expression correlates with clinical stage, histological grade, invasive behavior and survival rate in endometrial carcinoma[J]. Cancer lett,2002,184:105-116

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