抗体酶的研究与应用进展

The Progress of Abzyme Studies and Applications

抗体酶是一类以过渡态类似物为半抗原通过诱导免疫系统产生的具有类似天然酶催化活性的免疫球蛋白。它可促进许多用普通化学方法很难完成 ,或者天然酶尚未能催化的新奇转变。最近 ,抗体酶也显示出在许多领域的潜在应用价值。文章扼要介绍了抗体酶的设计策略 。

Abzymes that behave like enzymes can be elicited by immunizatio n with a hapten.They have been used to accomplish many novel transformations not attainable by current chemical methods or enzymes in nature. Recently, it has b een shown that abzymes can also have potential values in many areas. This articl e has reviewed the designing strategies of abzymes and their preparings and appl ications.