谷氨酸钠兴奋室旁核引起的升压效应及其与蓝斑-升压反应和A_1-降压反应间的关系

PRESSOR RESPONSE TO GLUTAMATE-INJECTION INTO HYPOTHALAMIC PARAVENTRICULAR NUCLEUS AND ITS RELATION TO PRESSOR RESPONSE OF LOCUS COERULEUS AND DEPRESSOR RESPONSE OF A_1

将L-谷氨酸钠(Glu)注入乌拉坦麻醉、箭毒化、人工呼吸大鼠的室旁核(NPV)或蓝斑内引起升压反应。蓝斑升压反应可被双侧室旁核内预先注射酚妥拉明或心得安明显衰减;双侧室旁核内预先注射酚妥拉明或荷包牡丹碱还可使Glu兴奋延髓A_1区引起的降压反应减小,但注射心得安对A_1-降压反应无明显影响。以上结果提示蓝斑-升压反应和A_1-降压反应均部分通过NPV实现,A_1降压过程中可能有NPV内GABA能抑制性中间神经元参与。

In urethane-anesthetized, tubocurarine-immobilized and artificially ventilatedrats, microinjection of L-glutamate (Glu) into hypothalamic paraventricular nu-cleus (NPV) or locus coeruleus (LC) induced a pressor response. The LC-pressorresponse could be attenuated by preinjection of phentolamine or propranolol intobilateral NPV; Preinjection of phentolamine or bicuculline into bilateral NPVcould also attenuate the depressor effect of A_1-excitation by Glu, but preinjectionof propranolol had no such effect; suggesting that the LC-pressor or A_1-depressoreffect is mediated partly by NPV, and GABA ergic inhibitory interneurons in NPVmay be involved in A_1-depressor response.