摘要
采用电磁血流量计测量家兔主动脉血流量(心输出量)的方法,观察47只麻醉家兔侧脑室注射(icv.)SP和毒扁豆碱对心输出量、血压和心率的影响及其相互关系。结果如下:(1)icv.SP(20μg)或毒扁豆碱(60μg),均产生明显的心输出量和血压增高,不改变心率。(2)SP的效应不能被icv.阿托品(150μg)所阻断。(3)毒扁豆碱的效应可被预先icv.SP拮抗剂(25μg)阻断。结果提示,脑内SP参与了胆碱能机制对血压的调节,ACh通过脑内SP起作用。
Using an electromagnetic flowmeter technigue, the cardiac output as mea-sured by blood flow in the aortic arch was measured during intracerebroventricularinjection (icv.) of Substance P (SP) and physostigmine in 47 anesthetized rabbits.Carotid artery blood pressure and heart rate were recorded. After icv of SP (20μg/20 μl) or physostigmine (60 μg/20μl), both cardiac output and mean arterypressure were increased. Pretreatment with icv. of atropine (150 μg/20μl) didnot alter the effect of SP, but the effect of physostigmine was blocked by pretreat-ment with SP blocker (25μg/20μl). These findings suggest that cerebral SPis involved in cholinergic mechanisms on the ccetral control of blood pressure.
出处
《生理学报》
CAS
CSCD
北大核心
1992年第2期192-196,共5页
Acta Physiologica Sinica
关键词
P物质
心输出量
血压
毒扁豆碱
Substance P (SP)
Acetylcholine (ACh)
cardiac output
blood pressure
intracerebroventricular injection(icv)
SP blocker
atropine
