摘要
用电击足底加噪音刺激的慢性应激方法,使成年雄性Sprague-Dawley大鼠获得持续性高血压。在这种慢性应激性高血压大鼠弓状核区微量注射0.3μL-谷氨酸钠(150mmol),可导致明显的血压下降。分别在中脑导水管周围灰质背内侧区和蓝斑区微量注射0.3μl和0.1μlβ—内啡肽抗血清后,上述弓状核神经元兴奋导致的降压效应明显减弱。结果表明,大鼠获得慢性应激性高血压后,弓状核神经元的兴奋具有明显降压作用,此作用可能与弓状核β—内啡肽能神经元的下行投射纤维的活动有关。
Hypertension was induced by chronic foot-shock and noise stress in adultmale Sprague-Dawley rats. Microinjection of 0.3 μl (150 mmol) sodium gluta-mate (Glu) into the nucleus arcuatus (ARC) elicited a significant depressor effect inrats with chronic stress-induced hypertension. The depressor effect induced byexcitation of ARC neurons was attenuated significantly by microinjection of 0.3μl β-endorphin antiserum (β-EPAS) into the dorso-medial periaquductal gray(PAG) or 0.1 μl into the area of locus coeruleus (LC) due to blockage of β-endorphinergic fibres from ARC to PAG or LC.
出处
《生理学报》
CAS
CSCD
北大核心
1992年第2期133-141,共9页
Acta Physiologica Sinica
关键词
应激
高压
弓状核
降压作用
stress
hypertension
nucleus arcuatus
periaqueductal gray
locus cosruleus
β-endorphin
