摘要
内皮素是血管内皮释放的生物活性多肽,具有强烈的收缩血管和促进血管平滑肌细胞增生肥大的效应。本工作在大鼠腹主动脉狭窄和高盐摄入引起的高血压模型上,观察到高血压动物血浆内皮素水平成倍增加(9.70±0.68vs。假手术动物4.11±0.33pg/ml,P<0.01)。应用特异的内皮素抗血清治疗,显著缓解了动物血压的升高(18.97±1.32vs.27.33±0.90kPa,P<0.01)和心肌肥大损伤。实验结果提示:内皮素是高血压的重要发病因素之一;拮抗内皮素可能是高血压病防治的新途径。
Endothelin is a bioactive polypeptide released from vascular endothelium,which has a strong action promoting vascular contraction, proliferation and hy-pertrophy of vascular smooth muscle cells. The present investigation was per-formed on the hypertensive rat produced by narrowing abdominal aorta and drink-ing saline. It was observed that the level of plasma endothelin in the hypertensiverats was doubled (9.70±0.68 vs. sham group 4.11±0.33 pg/ml, P<0.01), andadministration of specific endothelin-antiserum into hypertensive rats significantlyattenuated the increase in the blood pressure (18.97 + 1.32 vs. 27.33 + 0.09 kPain untreated hypertensive rats, P<0.01), and dramatically ameliorated malfunc-tion resulting from myocardial hypertrophy. The results suggest that endothelinis an important factor in the pathogenesis of hypertension, and that inhibition ofendothelin action may be a new effective way in prevention and therapy of hy-pertension.
出处
《生理学报》
CAS
CSCD
北大核心
1992年第3期290-294,共5页
Acta Physiologica Sinica
关键词
高血压
内皮素
抗血清
hypertension
endothelin
antiserum
