离体心肌“生理性”收缩的计算机伺服系统

USE OF A COMPUTER-CONTROLLED SERVO SYSTEM TO PRODUC “EPHYSIOLOGICAL” CONTRACTION OF ISOLATED RAT PAPILLARY MUSCLE

扩充了A/D接口的Z-80微机和编制的软件,与肌力计和力位移双态换能器组成伺服系统,可以自动控制换能器金属杆的工作状态和“后负荷”水平,使离体心肌产生时相顺序类同于射血心室的四个时相“生理性”收缩,从而获得心肌的张力长度关系、作功量等心肌力学信息,并可同步观察收缩末期张力长度关系和张力速度关系。

A computer-controlled servo system consisting of an ergometer with a force-displacement dual mode transducer, a Z-80 single-board microcomputer and adesigned software was constructed. This servo system can be used to generatephysiological contractio. in isolated rat papillary muscle, in which the muscle wentthrough a complete 4-phase cycle of force and length changes, similar to those un-dergone by muscle fibers in the beating heart during the cardiac cycle. This system is being used to investigate the tension-length relation and the net-work of isolated myocardium as well as the end-systolic tension-length relation andthe force-velocity relation simultaneously.