武汉地区SEN病毒感染的血清流行病学调查

Prevalence of SEN Virus Infection in Wuhan Area

目的 研究武汉地区SEN病毒 (SENV)感染状况。方法 采用套式聚合酶链反应 (n PCR)对 191例、6种不同人群血清中SENV DNA进行D亚型和H亚型分析。结果 SENV的感染率为 14 7% ,6种人群中SENV感染率的高低依次为血浆置换患者 (36 7% )、静脉吸毒者 (33 3% )、慢性乙型肝炎患者 (11 1% )、非甲～非戊型肝炎患者 (9 4 % )、重症肝炎患者 (8 3% )、正常人群 (5 6 % )。结论 输血和静脉吸毒是SENV感染的重要途径 。

OBJECTIVE To investigate the prevalence of SENV in Wuhan area. METHODS SENV-D and SENV-H DNA were detected in 191 cases who were divided into 6 groups with nested-PCR. RESULTS SENV-DNA positive rates were 14.7%(28/191) totally, from which 36.7% in plasmapheresis patients, 33.3% in intravenous drug users, 11.1% in chronic hepatitis B patients, 9.4% in hepatitis non A-E patients, 8.3% in fulminant hepatitis patients, respectively, in comparison with 5.6% in normal populations. CONCLUSIONS Plasmapheresis and intravenous drug abuse are high risk factors for SENV infection. SENV is not a causative agent for chronic virus patients to exacerbate.