217例非淋菌性尿道炎患者支原体检测及耐药性分析

Detection and Drug-susceptibility Analysis of Mycoplasma Isolated from 217 NGU Patients

目的 调查本地区非淋菌性尿道炎 (NGU)患者支原体感染情况及抗生素的耐药率。方法 采用法国生物梅里埃公司IST支原体试剂盒对 2 17例NGU进行人支原体 (Mh)和解脲脲支原体 (Uu)检测和药敏试验。结果 2 17例患者中Uu ,Mh的检测率分别为 2 5 %和 9 2 % ,混合感染率为 1 8% ,总检出率为 36 0 % ;Uu对强力霉素、交沙霉素、氧氟沙星、红霉素、四环霉素和普那霉素 (原始霉素 )的耐药率分别为 2 7 8%、9 3%、14 8%、4 4 4%、4 6 3%和 7 4 % ;Mh对上述药物的耐药率分别为 30 0 %、10 0 %、2 5 0 %、6 5 0 %、5 5 0 %和 15 0 %。结论 泌尿生殖道支原体感染主要以Uu为主 ,Mh次之 ,Uu和Mh的耐药率存在一定差异 ,治疗两种支原体感染以原始霉素和交沙霉素最好 。

OBJECTIVE To study the infection and antibiotic drug resistances of mycoplasma from the patients with non-gonococcal urethritis(NGU) in Xi′an areas. METHODS Mycoplasma hominis(Mh) and Ureaplasma urealyticum(Uu) as well as their drug susceptibilities were tested with IST mycoplasma detection kits produced by Bio-Merieux in France. RESULTS The mycoplasma infection rate was 36%,with Uu25.0%, Mh 9.2% and mixed infaction 1.8%, respectively. The drug resistance of Uu was as follows: doxycycline 27.8%, josamycin 9.3%, ofloxacin 14.8%, erythromycin 44.4%. tetracycline 46.3 and pristinamycin 7.4%. The resistances of Mh were 30.0%, 10.0%, 25.0%, 65.0%, 55.0% and 15.0%, respectively. CONCLUSIONS Mycoplasma infection in genitourinary tract is mainly due to Uu infection. Drug resistances of Uu and Mh are different, but they all show high susceptibility to pristinamycine and josamycin, and next ofloxacin and doxycycline.