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NO-样松驰因子在大鼠止血带休克中的作用 被引量:5

EFFECT OF NO-LIKE RELAXING FACTOR(NO-LRF) IN RAT TOURNIQUET SHOCK
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摘要 为探讨NO-样松驰因子(NO-LRF)在休克中的效应及其病理生理意义,本工作在大鼠止血带休克(ToS)模型上发现离体灌流的主动脉环对去甲肾上腺素的反应性降低,组织cGMP含量增加。用NO前体L-精氨酸(L-Arg)或NO合成阻断剂L-NNA,可溶性乌苷酸环化酶抑制剂亚甲蓝灌流,分别增强或减轻ToS动物主动脉的上述变化,而且这些药物的作用不受血管内皮是否存在的影响。实验结果提示非内皮细胞源的NO-LRF是引起ToS动物血管低反应性的因素之一。体内实验表明 L-Arg治疗缓解,而L-NNA恶化ToS病程,提示NO-LRF可能参与机体的适应保护机制。 On tourniquet shock (ToS) rat model, it was found that the reactivity of iso-lated perfused aortic ring to noradrenaline was decreased, while the cGMP contentof the aortic tissue was increased. These ToS-induced changes could be potenti-ated or attenuated respectively by perfusion with NO-precursor, L-arginine, or NO-synthesis inhibitor L-NNA independent of the presence of vascular endothelium.Guanylate cyclase inhibitor, methylene blue, could also attenuate the aortic rea-ctivity. All these results suggest that the aortic musculature can produce a NO-LRF factor capable of lowering the vascular reactivity of the ToS animals. ThatL-argine can ameliorate while L-NNA can exacerbate TOS, suggest that NO-LRF do play an adaptive role in the protective mechanism of the organism dur-ing ToS.
出处 《生理学报》 CAS CSCD 北大核心 1992年第6期576-582,共7页 Acta Physiologica Sinica
关键词 一氧化氮 环化磷酸乌苷 休克 nitric oxide cGMP tourniquet shock aorta endothelium
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参考文献2

  • 1董淑云,中华创伤杂志,1991年
  • 2汤健,循环系统的内分泌功能,1989年

同被引文献24

  • 1卫小春,张志强,韩来春.甘露醇对肢体缺血再灌注损伤的保护作用[J].中华骨科杂志,1995,15(6):370-372. 被引量:53
  • 2王凤君,赵云,谢尔凡,尤忠义.高效液相色谱法测定生物样品中磷脂含量[J].第三军医大学学报,1996,18(1):67-68. 被引量:18
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  • 8Knowles RG, Salter M, Brooks SL, et al. Anti-inflammatory gluccorticoids inhibit the induction by endotoxin of nitric oxide synthase in the lung, liver and aorta of the rat. Biochem Biophys Res Commun,1995,172(11):1042.
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