摘要
目的 :探讨中药长必安抑制大肠癌转移的机制。方法 :应用含 2 2 7个靶基因芯片分析长必安干预后的大肠癌裸鼠转移模型的基因表达谱差异。结果 :发现 p47LBC、DKPZP434A2 32 2与 syn-thetase- like protein m RNA等 3个基因在肠癌转移模型发生转移和未发生转移的癌组织中存在表达差异 ,长必安对后两个基因产生上调作用。结论
Objective: To investigate the effect mechanism of Changbi'an on the colorectal cancer metastasis. Methods:The difference of genes expression in the nude mice model with colorectal cancer metastasis was investigated by applying the cDNA micro array after treated with Changbi'an. Results: There were different of the p47LBC, DKFZP434A2322 and synthetase like protein mRNA genes expression in the tissues with colorectal cancer metastasis or without metastasis. Changbi'an could improve those genes expression. Conclusion:Changbi'an may play a certain role on regulating multiple metastasis relating oncogene.
出处
《浙江中西医结合杂志》
2003年第11期670-672,共3页
Zhejiang Journal of Integrated Traditional Chinese and Western Medicine
基金
"九五"国家科技攻关课题基金资助项目( NO:96 90 6 0 70 3)
