米索前列醇不同给药途径预防剖宫产术后出血的临床观察

The Clinical Effectiveness of Misoprostol Used in Different Ways on Pre venting Postpartum Hemorrhage in Cesarean Section

目的 :观察米索前列醇不同给药途径预防剖宫产术中及术后出血的临床效果。方法 :选择 10 0例剖宫产病人随机分为A组 50例 ,B组 50例 ,于术中胎儿娩出后分别直肠给予和口服米索前列醇 60 0 μg ,观察两组术中胎盘娩出及术后 2h出血量。结果 :术中胎盘娩出及术后 2h平均出血量A组为 (2 0 7± 3 5.4)ml,B组为 (2 10± 46.0 )ml,两组比较差异无显著性(P >0 .0 5)。但服药后出现胃肠道反应、寒颤、发热等副反应B组明显高于A组 (P <0 .0 5)。结论 :采用米索前列醇 60 0 μg直肠给药途径预防剖宫产术中及术后出血更为安全有效。

Objective: To observe the clinical effectivene ss of Misoprotol used in different ways on preventing postpartum hemorrhage in c esarean section. Methods: 100 women with cesarean section were assigned randomly to group A (50 Patients) and group B (50 patients).Six hundred μg Miso prostol were given through intra-rectum or orally respectively while the fetal was delivering with operation.The amount of hemorrhage from placenta expulsion t ill 2 hours after delivering was colle cted and examined. Results: The average hemorrhage in group A was 207±35.4 ml,in group B was 210±46.0 ml.There was no significant di fference between the two groups ( P >0.05). The rate of side effects such as gastrointestinal symptoms,shiver and fever in group B was significantly hig her than in group A ( P <0.05). Conclusion: Six hundred μ g misoprostol used in intra-rectum on preventing postpartum hemorrhage in cesar ean secti on is more safe and more effective, simple and convenient.