高胆固醇血症家兔红细胞在交、直流电场中的电泳行为

THE ERYTHROCYTE ELECTROPHORESISES OF RABBITS WITH HYPERCHOLESTEROLEMIA IN AN AC AND A DC ELECTRIC FIELDS

本文对高胆固醇血症家兔红细胞在交、直流电场中的电泳行为进行了多指标测定,结果显示,高脂组与正常组相比红细胞聚集能力增强,变形能力及膜流动性下降,表明高脂血症可能较易导致血栓形成。中药有效成分8501有对抗高脂引起的红细胞上述改变的作用,提示8501可能对血栓和动脉粥样硬化斑块形成有防治作用。

The cell electrophoresis and dielectrophoresis of the erythrocytes in rabbits with hypercholesterolemia were measured. The results ihdicated that the aggregation of these erythrocytes was inereased, while thier deformation and membrane fluidity were decreased compared with the control. It suggests that the hypercholesterolemia may be one of the reasons which causes the thrombosis. The results also showed that 8501 (the effective principle of the chinese herb) could regulate above changes of the erythrocytes, which implied that 8501 may have benefit in preventing and treating thrombosis and atherosclerosis.