摘要
本文讨论了药物动力学参数已知时符合一级并行米氏消除药物最优给药方案设计的一种数值方法.该方法同样适用于一级并行米氏消除的特例——单一米氏消除过程的最优给药方案设计.
In this paper, the aulhors have proposed a simple numerical method for the optimum target dose-giving design of the drugs obeying parallel first order and Michaelis-Menten elimination kinetics,inputed by multiple subcutaneous or oral Administration. By this method, can get a provocative dosage D~*. After D~* has been given the plasma concentrations will keep in a target steady-estate with a maintenance dose D inputed with a given or choosen interval. This method is optimum that it can make the plasma concentrations reach a target steady-state most quickly and at the same time keep the steady-state above the minimum effective level(MEL) with a longest interval under some practical restrictions. The design method suggest is applicable to the drugs obeying first order or Michaelis-Menten elimination kinetics, which are two special cases of the parallel first order elimination kinetics.
出处
《生物数学学报》
CSCD
北大核心
1992年第2期127-132,共6页
Journal of Biomathematics
关键词
米氏消除
药物动力学
数学模型
Pharmacoknetics
Numerical method
Bioavailability
Michaelis-Menten elimination
