一种尼尔雌醇-甲地孕酮周期新疗法

A New Therapy With Nylestriol-Megestrol Acetate in Sequential Cyclic Treatment

本文报告了应用长效尼尔雌醇和甲地孕酮序贯周期疗法治疗84例闭经患者,其中原发闭经者13例,继发闭经者71例,后者中有47例诊断为高促性腺激素性闭经。结果所有病人在用药后均产生撤退性子宫出血。在用药一年以上的12例病人中,血清中FSH和LH值明显下降,而血清E_2明显上升,其中10例B超检查示有卵泡发育或/和排卵,并有3例获得妊娠。其中一例于妊娠34周时活产一健康婴儿,流产和人工流产各一例,因此本周期疗法具有有效、方便、经济、安全和副作用少等优点。

A clinical study was carried out on sequential treatment with long-acting Nylestriol -Megestrol acetate in 84 amenorrhea patients. The patients included 13 cases of primary amenorrhea and 71 cases of secondary amenorrhea, of which 47 cases were hypergonadotropic amenorrhea (HGA). Results showed that treatment could induce withdrawal bleeding in all cases. After treatment for more than 12 months, 12 of 47 cases showed a decrease of the mean serum FSH and LH levels and an increase of serum E_2 (P<0.01). Ultrasonography revealed follicular development and ovulation in 10 cases, 3 cases of them got pregnant. Case 9 delivered a healthy baby at 34 weeks' gestation, another aborted spontaneously and the other had an induced abortion. This therapy is effective, convenient, economic, safe and with few side effects.