药物对进驻高原青年睡眠剥夺及力竭运动时做功效率的影响

Effect of Some Medicine on Work Efficiency During Sleep Deprivation and Exhaustive Exercise in Men at High Altitude

目的 探讨红景天与乙酰唑胺对进驻高原青年做功效率的影响。方法 将进驻海拔3700m 1个月的24名健康青年随机分为3组,每组8人,让受试者用EGM型踏车功量机做坐位踏车运动,初始负荷25 W,每3min递增25 W,直至力竭。记录运动心率及运动终止5minn时恢复心率;第2次实验为24h睡眠剥夺后;第3次实验为3组受试者分别口服三普红景天、乙酰唑胺和安慰剂20 d时;第4次实验为服药后24h睡眠剥夺后,实验方法与第1次相同。结果 红景天和乙酰唑胺组服药后与服药后睡眠剥夺后在运动功率达225W时心率较服药前、睡眠剥夺后及对照组降低,差异显著(P<0.05);红景天组和乙酰唑胺组服药后与服药后睡眠剥夺后运动终止5min时恢复心率较服药前、睡眠剥夺后及对照组明显降低,差异非常显著(P<0.01)。结论 红景天和乙酰唑胺均能改善进驻高原青年的心功能和提高做功效率,红景天药效优于乙酰唑胺。

Objective To study the effect of rholida and acetazolamldeon the work efficiency during sleep deprivation and exhaustive exercise in health young men at high altitude. Methods 24 sub jects, exposed to 3 700m altitude for 1 month, were randomly divided into rholida, acetazolamide and placebo group, each 8 in a group, and constantly pedalled the EGM efficiency bicycle (initial load25W, increase ptogressively SOW per 3 min to exhaustion) ,to calculated their exercise heart rate (HR225W) and the recovered HR at 5 min, repeated the test after depriving sleep for 24 hours and after taking medicine for 20 days. Results As compared with placebo group and before taking medicine or deprivng sleep, the HR225W were decreased significantly in rholida group and acetazolamide group after taking medicine for 20 daysor depriving sleep for 24 hours( P < 0.05 ) , and the recovered HR at 5 min also lower (P < 0.05 ). Conclusion Both rholida and acetazolamide canimprove the cardiac function and work efficiency at high altitude, and rholida have an slightly advantage over acetazolamide.