摘要
目的 研究内吗啡肽 1(EM 1)水溶液最稳定pH值及预测EM - 1水溶液室温贮存期。方法 采用HPLC法作为测定方法 ,利用恒温加速实验研究EM 1水溶液的稳定性。结果 绘制出pH =速率图 ,恒温加速实验得到Arrehnius方程及动力学参数。结论 EM 1水溶液最稳定pH值为 4 .5～ 4 .8,预测EM 1室温 ( 2 5℃ )的t1 2 为 4
Aim To study the most stable pH value of endomorphin-1 solution and toestimate the shelf-life of EM-1 solution. Methods The content of EM-1 in its solution was determinedby HPLC, and stability was studied by accelerated tests. Results The most stable pH value of EM-1solution was observed. By the accelerated tests we obtained the Arrhe-nius relationship and thepharmacokinetic parameters. Conclusion The most stable pH value of EM-1 solution is 4.5 -4.8. Thet_(1/2)(25℃) is 45 d.
