摘要
Objective To study the expression of p16, cyclin D1, Rb and phosphorylated Rb(Ser795) in the esophageal squamous cell carcinoma. Methods Immunohistochemistry was performed and analysed on 34 cases of paraffin-embedded tissues. Results The expression of phosphorylated Rb(Ser795) was positively correlated to that of cyclin D1 (r= 0.401, P= 0.021) and inversely to that of p16 (r= -0.348, P= 0.044). In stepwise regression and the best subset regression, the expression of p16 (P=0.034) and phosphorylated Rb(Ser795) (P= 0.030) were the only determinants of the mitotic index. Conclusion The expression of phosphorylated Rb(Ser795) could be considered as a mark of the interaction between p16 and cyclin D1. The detection of phosphorylated Rb, p16 and cyclin D1 will be possibly helpful to the oncogenesis investigation on the esophageal carcinoma.
Objective To study the expression of p16, cyclin D1, Rb and phosphorylated Rb(Ser795) in the esophageal squamous cell carcinoma. Methods Immunohistochemistry was performed and analysed on 34 cases of paraffin-embedded tissues. Results The expression of phosphorylated Rb(Ser795) was positively correlated to that of cyclin D1 (r= 0.401, P= 0.021) and inversely to that of p16 (r= -0.348, P= 0.044). In stepwise regression and the best subset regression, the expression of p16 (P=0.034) and phosphorylated Rb(Ser795) (P= 0.030) were the only determinants of the mitotic index. Conclusion The expression of phosphorylated Rb(Ser795) could be considered as a mark of the interaction between p16 and cyclin D1. The detection of phosphorylated Rb, p16 and cyclin D1 will be possibly helpful to the oncogenesis investigation on the esophageal carcinoma.
基金
Cetravailab啨n啨fici啨dusupportduFondsduD啨veloppementScientifiqueShanghai (0 2ZB14 0 47)etduFondsduTechniqueScientifiqueVniversitaireShanghai(0 2BK0 7)
