抗癫痫药血药浓度监测结果的分析

Analysis of the Results from Monitoring Serum Antiepileptic Concentrations

目的 探讨用药剂量、年龄、性别及合并用药对3种抗癫痫药卡马西平(CBZ)、苯妥英钠(PHT)和苯巴比妥(PB)血药浓度的影响,评价血药浓度监测对癫痫患者临床用药的指导意义。方法 采用化学发光法对我院333例癫痫患者用药后的血药浓度进行了578次监测,对监测结果进行分析与评价。结果 服用PHT的100例次其血药浓度达到有效范围的占32.0％,使用PB的136例次和使用CBZ的342例次该值分别为44.1％和41.5％。结论 血药浓度监测对于临床用药的科学合理化、安全有效性有重要价值。

Objective To explore the influences of dose, age, sex and Combined administration of drugs on plasma concentrations of antiepileptics: carbamazepine(CBZ), phenytoin(PHT) and Phenobar-bital (PB), to understand the significance of plasma concentration monitoring in guiding clinical administration of medicine to epileptic patients. Methods The plasma medicine concentrations of 333 patients with epilepsy treated with antiepileptics in our hospital was assayed 578 times by using chemilumines-cence method, and the results were analyzed and evaluated. Results In 100 cases of patients treated with PHT, 32.0% patients plasma concentration were within the effective therapeutic range, while the percentages of 136 patients with PB and 342 patients with CBZ were 44. 1% and 41, 5% respectively. Conclusions Plasma concentration monitoring is of great value in practicing scientific, rational, safe, effective administration of medicine in the treatment of epilepsy.