扭转痉挛患者基底节的电生理研究

Neuronal Activity in the Basal Ganglia in Patients with Torsion Dystonia

目的 观察扭转痉挛患者基底节神经元的电活动特点。方法 在对6例扭转痉挛患者行微电极导向脑内核团毁损术治疗的同时,利用微电极记录技术分别对4例患者的内苍白球、2例患者的丘脑底核神经元电活动进行了记录和分析。结果 内苍白球神经元主要表现为高度不规律的持续低频群发放电,间有暂歇,其平均自发放电频率为(26.4±13.9)Hz,电活性较低。丘脑底核神经元主要表现为不规律的发放,其平均自发放电频率为(49.1±9.2)Hz,电活性较高。结论 扭转痉挛患者基底节存在功能异常。

Objective To investigate the neuronal activity in the basal ganglia in patients with torsion dystonia. Methods Using the electrophysiological recording system and Poly-view Software, the neuronal activity was recorded from the internal segment of the globus pallidus (GPi) in 4 patients and the subthalamic nucleus (STN) in 2 patients and assessed for the mean discharge rate and the pattern of spontaneous activity. Results The mean discharge rate of neurons in GPi was (26. 4±13. 9)Hz, and the pattern of spontaneous neuronal activity was highly irregular, occurring in intermittent grouped discharges separated by periods of pauses. STN neurons had an irregular discharge pattern and a mean discharge rate of (49. 1±9. 2) Hz. Conclusions It is suggested that the neuronal activity of GPi was reduced and the discharge was irregular, and STN neuronal activity was elevated in patients with torsion dystonia.