肝硬化患者生长激素水平与肝功能及营养的关系

Relationship between serum growth hormone, liver function and nutritional status in liver cirrhosis

目的 探讨肝硬化患者生长激素 (GH)与肝功能和营养状况的关系。方法 测定 4 2例肝硬化患者和 2 1例健康受试者的血清生长激素水平 ,并对肝硬化患者进行主观综合营养评估 (SGA)及Child Pugh分级。结果 肝硬化患者血清GH测定值 (7.2 3± 7.0 6 ) μg/L较正常对照组 (1.4 0± 2 .2 7) μg/L显著性升高 (P <0 .0 1) ,并随着Child Pugh分级积分的增加而升高 (P <0 .0 1)。依据SGA分组后 ,SGA1、SGA2 及SGA3 3组肝硬化患者的GH水平与正常对照组之间差异有统计学意义 (P <0 .0 5 ) ,SGA1与SGA3 (P <0 .0 5 )及SGA2 与SGA3 (P <0 .0 1)之间差异亦有统计学意义。结论 肝硬化患者存在高生长激素血症 。

Objective To explore the relationship between serum growth hormone(GH),liver function and nutritional status in the patients with liver cirrhosis.Methods Serum GH level was determined in 42 cases of liver cirrhosis and 21 cases of healthy control subjects.And the patients of liver cirrhosis were conducted with subjective global assessment(SGA) and Child Pugh classification.Results Serum GH value in the liver cirrhosis group was ( 7.23 ± 7.06 ) μg/L,significantly higher than the control one ( 1.40 ± 2.27 ) μg/L (P< 0.01 ).After dividing into different groups by SGA,all GH values in the three liver cirrhosis groups,SGA 1,SGA 2 and SGA 3 had significant differences with the control group(P< 0.05 ).There were also differences between SGA 1, and SGA 2(P< 0.05 ),as well as between SGA 2 and SGA 3(P< 0.01 ).Conclusion High serum GH level occurs in the patients of liver cirrhosis.Increased GH level correlates with injury of liver function and the nutritional status.