沙棘籽渣和果渣中黄酮对小鼠糖代谢的影响

Effect of Flavonoids from the Seed and Fruit Residue of Hippophae rhamnoides L. on Glycometabolism in Mice

目的 :研究沙棘籽渣和果渣黄酮对小鼠糖代谢的影响。方法 :健康雄性昆明种小鼠随机分为对照组 ,沙棘籽渣黄酮 (FSH)低、中、高剂量组和沙棘果渣黄酮 (FFH)低、中、高剂量组 ,对照组小鼠灌胃生理盐水 ,其余各组小鼠每天灌胃相应药物。灌胃 7d、14d、16d时 ,测小鼠的血糖、血脂水平 ;16d后 ,作糖异生试验 ,同时作肝糖原分析。结果 :正常小鼠灌胃FSH或FFH后 ,血糖和血脂水平低于对照组 ;同时对小鼠糖异生具明显的抑制作用。结论 :FSH和FFH能降低正常小鼠的血糖和血脂水平 ,且对血糖代谢的影响与控制糖异生有关。

Objective: To investigate the effect of flavonoids from the seed residue and fruit residue of Hippophae rhamnoides L (FSH and FFH) on glycometabolism in mice Method: The healthy male mice were randomly divided into control group, three FSH treatment groups and three FFH treatment groups FSH(50,100,150 mg/kg) and FFH (50,100,150 mg/kg) were given intragastorically(ig) At the same time, the mice of control group were given physiological saline The levels of serum glucose, serum cholesterol were determined when it lasted 7 and 14 days After 16 days glyconeogenesis test was made and liver glycogen was analyzed Result: The levels of serum glucose, serum cholesterol and serum triglyceride were significantly reduced by high dose FSH and FFH The glyconeogenesis was also obviously inhibited by FSH and FFH Conclusion: FSH and FFH can decrease the levels of blood glucose and lipid in normal mice, and the effect of FSH and FFH on glycometabolism may be related to the control of glyconeogenesis