^(18)F-FDG PET显像诊断原发性鼻咽癌的价值

Diagnostic value of ^(18)F-FDG PET imaging in primary nasopharyngeal carcinoma

目的 探讨18F 脱氧葡萄糖 (FDG)PET显像对原发性鼻咽癌的诊断价值。方法 对 51例受检者行18F FDGPET显像 ,其中 3 1例行病理组织学检查 ,最后诊断根据病理组织学检查结果和临床随访。结果 18F FDGPET显像诊断原发性鼻咽癌的灵敏度为 96.0 0 % ,特异性为 76 92 % ,阳性预测值为 80 .0 0 % ,阴性预测值为 95 2 4% ,准确性为 86 2 7%。鼻咽癌、鼻咽炎症和无鼻咽病变组标准摄取值 (SUV)均值比较 ,3组间差异有显著性 (F =2 1 3 0 ,P <0 0 1)。结论 18F

Objective To study the diagnostic value of 18 F-fluorodeoxyglucose (FDG) imaging in primary nasopharyngeal carcin oma (PNC). Method s All fifty-one patients underwent 18 F-FDG PET imaging an d thirty-one of them with biopsy data. The diagnosis was based upon pathologic and clinical follow-up studies. Results Diagnostic sensitivity, specificity and accuracy of 18 F-FDG PET i maging in PNC was 96.00%, 76.92% and 86 27%,respectively, whereas the positive predictive value was 80.00% and the negative predictive value was 95.24 %. There was significant difference in mean SUV values among PNC, nasopharyngiti s and non-nasopharyngeal lesion groups. Conclusion The high sensit ivity and negative predictive value of 18 F-FDG PET imaging for d etection of PNC suggest that it has important value in clinical practice.