摘要
目的 研究心肌青心酮预处理和缺血预处理对离体大鼠心脏缺血 /再灌注后心肌功能的影响。方法 以离体大白鼠工作心脏模型 ,比较经青心酮预处理和缺血预处理 ,心肌缺血再灌前后左室压 (LVP)、左室舒张末期压 (LVDEP)、左心室内压上升及下降最大速率 (±dt/dpmax )、主动脉压 (AP)、冠脉流量 (CF)、主动脉流量 (AF)和测定冠脉流出液乳酸脱氢酶 (LDH) ,心肌三磷酸腺苷 (ATP)含量及自灌注停搏液至完全停搏的时间 (AT)。结果 青心酮预处理和缺血预处理产生相似的心肌保护作用 ,明显促进心肌缺血再灌后心肌功能的恢复 ,增进心脏的收缩功能、心肌ATP含量。结论 青心酮预处理对心脏模拟体外循环的缺血再灌损伤具有保护作用 。
Objective To investigate the protective effect of 3,4-dihydroxyacetophenone(DHAP),Pretreatment(DPT)and Ischemic Preconditioning(IPC)in isolated rat hearts which suffer from ischemia/reperfusion injury.Methods The model of Langendorff perfused isolated rat heart was used to study the effects of DPT on left ventricular pressure(LVP)、left ventricular end-diastolic pressure(LVDEP)、the maximal rate of rise and fall in left ventricular pressure(±dp/dt max)、aortic pressure(AP)、coronary flow(CF)、aortic flow(AF),concentrations of ATP level pre-and post-ischemia/reperfusion.Results Compared with only ischemia/reperfusion group,DPT and IPC enhanced the recovery of cardiac hemodynamics and promoted!the recovery of contractile function,increased ATP level.Conclusion DPT and IPC have similar effects of anti-ischemia and reperfusion injury,and may play an important role in the future clinic cardiac surgery.
出处
《深圳中西医结合杂志》
2003年第5期277-279,282,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
关键词
青心酮
缺血预处理
心肌保存
心肌再灌注
DHAP
Ischemic preconditioning
Myocardial protection
Myocardial reperfusion
