腹腔海水浸泡对失血犬的影响

Effect of celiac seawater immersion to hemorrhagic dogs

目的 探讨腹腔海水浸泡对失血犬的影响。方法 将实验犬 2 1条随机均分为失血组 (A组 )、腹腔海水浸泡组 (B组 )、失血及腹腔海水浸泡组 (C组 )。观察各组犬腹腔海水浸泡前后心排血量 (CO)、平均动脉压 (MAP)和血浆渗透压、乳酸、丙二醛 (MDA)、及超氧化物歧化酶 (SOD)水平变化。结果 C组动物腹腔海水浸泡 3hCO、MAP、SOD水平分别由浸泡前 ( 4 .3 5± 0 .5 0 )L/min、( 2 0 .1± 1.3 )kPa、( 182 .1± 14 .5 )U /L显著降低至 ( 1.3 7± 0 .11)L/min、( 9.6± 2 .7)kPa、( 5 1.4± 11.8)U /L ,而MDA及乳酸水平则分别由浸泡前 ( 5 .9± 0 .2 ) μmol /L、( 2 .3± 0 .4)mmol/L显著升高至 ( 2 6.4± 3 .2 ) μmol/L、( 8.7± 1.4)mmol/L(与A、B组比较P <0 .0 5 )。 结论 腹腔海水浸泡可加重失血犬血流动力学紊乱及自由基损伤。

Objective To study the effect of seawater immersion to hemorrhagic dogs.Methods Twenty-one dogs were randomly divided into hemorrhagic group (group A,n=7),celiac seawater immersion group (group B,n=7) and hemorrhagic + celiac seawater immersion group (group C,n=7).The changes of CO,MAP,SOD,MDA,plasma osmotic pressure and lactic acid levels were observed.Results Levels of CO,MAP and SOD were decreased significantly from (4.35±0.50) L/min,(20.1± 1.3) kPa,(182.1±14.5) U/L to (1.37±0.11) L/min,(9.6±2.7) kPa,(51.4±11.8) U/L,but the levels of MDA and lactic acid increased significantly from (5.9±0.2) μmol /L,(2.3±0.4) mmol/L to (26.4±3.2) μmol/L,(8.7±1.4) mmol/L respectively 3 h after celiac seawater immersion in group C as compared with those in group A or B(P<0.05).Conclusion Open celiac seawater immersion can result in more serious hemodynamic changes and free radical damage in hemorrhagic dogs.