米非司酮用于大鼠足月妊娠引产对母鼠心肌组织的影响

Effects of mifepristone for labor induction of full-term pregnancy on rat myocardial tissue

目的 探讨米非司酮用于大鼠足月妊娠引产对母鼠心肌组织的影响。方法 将孕鼠随机分为实验组和对照组 ,每组各 5例 ,于怀孕第 2 0天分别用 1ml麻油加米非司酮 (11.5± 1.0 )mg和 1ml麻油灌胃。分娩后 2 4h内取材 ,作透射电镜及体视学观察。结果 实验组心肌细胞分布均匀 ,核未见明显变化。部分肌细胞胞质水肿 ,线粒体明显肿胀 ,嵴断裂 ,呈空泡样变或破裂。间质毛细血管内皮细胞胞质水肿 ,线粒体肿胀 ,基底膜完整。实验组线粒体的平均体积和体积密度与对照组相比差异有显著性 (P <0 .0 5 ) ,两组间线粒体数密度的差异无显著性 (P >0 .0 5 )。结论 米非司酮用于大鼠足月妊娠引产 。

Objective To investigate the effects of mifepristone for labor induction of full-term pregnancy on the rat myocardial tissue. Methods 10 pregnant rats were randomly divided into two groups, control group (n=5) gavaged with 1 ml sesame oil and experimental group (n=5) with 1 ml sesame oil +mifepristone (11.5±1)mg on the 20th day of pregnancy. 24 h after delivery, myocardial tissues of the mature rats were obtained and prepared for transmission electron microscopic examination. The mitochondria parameters were analyzed by stereology. Results In comparison with the control group, the myocardial tissue of the experimental group displayed the following morphological changes: Some muscle cells were edematous, mitochondria were markedly swollen with decrease of cristae. In the interstitium, the capillary endothelial cells' cytoplasm were also swollen. In the experimental group, the mean volume and volume density of mitochondria increased obviously, but no significant change in the numerical density. Conclusion Using mifepristone for labor induction of full-term pregnancy can cause hypoxic damage in rat myocardial tissue.