严重急性呼吸综合征患者细胞免疫功能的变化

Subgroups of Peripheral Blood T Lymphocytes in Elderly Patients with Severe Acute Respiratory Syndrome

为探讨老年严重急性呼吸综合征(SARS)患者细胞免疫功能的变化,为临床提供理论依据,对211例SARS患者按不同年龄、疾病严重程度以及激素使用情况分组。采用流式细胞技术测定患者不同病程的外周血T淋巴细胞亚群的变化。结果所有患者发病后均出现T淋巴细胞的明显下降,低谷出现于发病后22.83d。老年SARS患者疾病极期T细胞各亚群绝对数均低于中青年患者,重症患者低于轻症患者(P<0.01)。激素使用与否以及剂量大小对T细胞影响不大。提示SARS患者发病初期细胞免疫功能受到明显损害,老年、重症SARS患者的损害更为显著,外周血CD3+、CD4+、CD8+细胞下降的程度可作为病情轻重及预后判断的指标之一。

The objective was to investigate the changes of subgroups of peripheral blood T lymphocytes in elderly patients with severe acute respiratory syndrome(SARS).Methods Subgroups of peripheral blood T lymphocytes in211patients,including40elderly patients with SARS were detected by flow cytometer.Results The number of CD 3 ,CD 4 ,and CD8lymphocytes all significantly decreased in acute phase of patients with SARS.The counts of CD 3 ,CD 4 ,and CD8lymphocytes decreased more apparently in elderly patients with SARS.Conclusion The cellular immunity is damaged in SARS patients,more apparently in elderly patients with SARS.