SARS患者T细胞及其亚群数量变化的动态观察

Changes of T cell and its Subgroup in Patients with Severe Acute Respiratory Syndrome

为观察SARS临床治愈患者细胞免疫功能的动态变化情况并初步分析其原因,选择SARS临床治愈患者93人,在住院期间并随访3个月,定期检测细胞免疫功能,前瞻性观察其变化。发现SARS患者的免疫功能在极期下降到最低点,呈现一过性免疫缺陷,此后逐渐恢复,在病程的60d恢复至正常水平,但部分患者出现CD4+/CD8+比值倒置现象。同时发现在不同年龄组,SARS引起的免疫损伤不同,恢复情况亦不同,差异显著(P<0.05)。T细胞及其亚群的变化与SARS的发生、发展和转归有一定相关性,多数患者免疫功能受损是可逆的,但细胞免疫功能的恢复较晚并存在恢复后期的CD4+/CD8+比值倒置现象,有待进一步的随访研究。

The objective was to observe the development and change of cell immunological function and analyze the cause.Prospective study was designed to analyze the development and changes of im-munological function in the following-up patients.Immunological function(CD 3+ ,CD 4+ ,CD 8+ )de-creased most in the period of fastigium in SARS patient,and then recovered the the normal standard slowly on the60th days after onset.At the same time the ratio of CD 4+ /CD 8+ was inverted in some pa-tients of SARS.Different immunological functional damage(CD 3+ ,CD 4+ ,CD 8+ )were found in differ-ent age groups(P<0.05).The change of immunological function are associated with the development of SARS,and the damage of immunological function is reversible.But we should pay attention to the phe-nomenon of inverting in the ratio of CD 4+ /CD 8+ .